Abstract

We report a novel method to regenerate a biosensor surface in microfluidics. By applying a low DC voltage (0.9V) between two electrodes, the sensing surface resets to be reusable/reconfigurable through electrodesorption of short-chain self assembled monolayers (SAMs). This method is free from electrolysis (HER (Hydrogen Evolution Reaction)) and electrode oxidation (peel-off). Real-time SPR (Surface Plasmon Resonance) measurements demonstrate streptavidin-bound COOH-SAM completely desorbs and CH3-terminated SAM forms on the sensing surface to capture a target protein, fibrinogen, in a microfluidic device. The repeatability of the electrodesorption method is also presented.

Original languageEnglish (US)
Title of host publicationTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages943-946
Number of pages4
DOIs
StatePublished - Dec 11 2009
EventTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems - Denver, CO, United States
Duration: Jun 21 2009Jun 25 2009

Publication series

NameTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

Other

OtherTRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
CountryUnited States
CityDenver, CO
Period6/21/096/25/09

Keywords

  • Biosensor
  • Electrochemical reductive desorption
  • Electrode peel-off
  • Hydrogen evolution reaction (HER)
  • Microfluidics
  • Reusable
  • Self-assembled monolayers (SAMs)

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'A regenerative biosensing surface using electrochemical desorption of self-assembled monolayer in microfluidics'. Together they form a unique fingerprint.

  • Cite this

    Choi, S., & Chae, J. (2009). A regenerative biosensing surface using electrochemical desorption of self-assembled monolayer in microfluidics. In TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 943-946). [5285972] (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2009.5285972