A regenerative biosensing surface using electrochemical desorption of self-assembled monolayer in microfluidics

Seokheun Choi; Junseok Chae

doi:10.1109/SENSOR.2009.5285972

A regenerative biosensing surface using electrochemical desorption of self-assembled monolayer in microfluidics

Seokheun Choi, Junseok Chae

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

We report a novel method to regenerate a biosensor surface in microfluidics. By applying a low DC voltage (0.9V) between two electrodes, the sensing surface resets to be reusable/reconfigurable through electrodesorption of short-chain self assembled monolayers (SAMs). This method is free from electrolysis (HER (Hydrogen Evolution Reaction)) and electrode oxidation (peel-off). Real-time SPR (Surface Plasmon Resonance) measurements demonstrate streptavidin-bound COOH-SAM completely desorbs and CH₃-terminated SAM forms on the sensing surface to capture a target protein, fibrinogen, in a microfluidic device. The repeatability of the electrodesorption method is also presented.

Original language	English (US)
Title of host publication	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Pages	943-946
Number of pages	4
DOIs	https://doi.org/10.1109/SENSOR.2009.5285972
State	Published - Dec 11 2009
Event	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems - Denver, CO, United States Duration: Jun 21 2009 → Jun 25 2009

Publication series

Name	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems

Other

Other	TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems
Country/Territory	United States
City	Denver, CO
Period	6/21/09 → 6/25/09

Keywords

Biosensor
Electrochemical reductive desorption
Electrode peel-off
Hydrogen evolution reaction (HER)
Microfluidics
Reusable
Self-assembled monolayers (SAMs)

ASJC Scopus subject areas

Hardware and Architecture
Electrical and Electronic Engineering

Access to Document

10.1109/SENSOR.2009.5285972

Cite this

Choi, S., & Chae, J. (2009). A regenerative biosensing surface using electrochemical desorption of self-assembled monolayer in microfluidics. In TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 943-946). Article 5285972 (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems). https://doi.org/10.1109/SENSOR.2009.5285972

A regenerative biosensing surface using electrochemical desorption of self-assembled monolayer in microfluidics. / Choi, Seokheun; Chae, Junseok.
TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems. 2009. p. 943-946 5285972 (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Choi, S & Chae, J 2009, A regenerative biosensing surface using electrochemical desorption of self-assembled monolayer in microfluidics. in TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems., 5285972, TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems, pp. 943-946, TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems, Denver, CO, United States, 6/21/09. https://doi.org/10.1109/SENSOR.2009.5285972

Choi S, Chae J. A regenerative biosensing surface using electrochemical desorption of self-assembled monolayer in microfluidics. In TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems. 2009. p. 943-946. 5285972. (TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems). doi: 10.1109/SENSOR.2009.5285972

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abstract = "We report a novel method to regenerate a biosensor surface in microfluidics. By applying a low DC voltage (0.9V) between two electrodes, the sensing surface resets to be reusable/reconfigurable through electrodesorption of short-chain self assembled monolayers (SAMs). This method is free from electrolysis (HER (Hydrogen Evolution Reaction)) and electrode oxidation (peel-off). Real-time SPR (Surface Plasmon Resonance) measurements demonstrate streptavidin-bound COOH-SAM completely desorbs and CH3-terminated SAM forms on the sensing surface to capture a target protein, fibrinogen, in a microfluidic device. The repeatability of the electrodesorption method is also presented.",

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A regenerative biosensing surface using electrochemical desorption of self-assembled monolayer in microfluidics

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Keywords

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