A prospective study of pulmonary function and gas exchange following liver transplantation

M. J. Krowka, E. R. Dickson, R. H. Wiesner, R. A F Krom, B. Atkinson, Denis Cortese

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Pulmonary function and gas exchange were prospectively studied in 95 patients before and 9 to 15 months following liver transplantation. Pretransplant, the most common PF abnormality was impaired efficiency of gas exchange as measured by Dss. As a group, the mean Dss was 78.0 ± 16.6 percent predicted and was found to be less than 80 percent predicted in 50 patients. As a group, patients with the most severe liver diseases clinically (Child's C classification) had the lowest mean Dss pretransplant. Posttransplant, three findings were of clinical importance: PaCO2 significantly improved posttransplantation, suggesting a resolution of pretransplant respiratory alkalosis. Expiratory airflow obstruction, measured by a change in the FEV1/FVC, was extremely uncommon posttransplant. Mean Dss improved significantly in patients with Child's C severity of liver disease. The most frequent deteriorations in Dss statistically were associated with posttransplant thoracotomy, ARDS, nonspecific pneumonitis, significant pleural effusions and hepatic retransplantation.

Original languageEnglish (US)
Pages (from-to)1161-1166
Number of pages6
JournalChest
Volume102
Issue number4
StatePublished - 1992
Externally publishedYes

Fingerprint

Pulmonary Gas Exchange
Liver Transplantation
Prospective Studies
Liver Diseases
Respiratory Alkalosis
Pulmonary Ventilation
Pleural Effusion
Thoracotomy
Pneumonia
Gases
Liver

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Krowka, M. J., Dickson, E. R., Wiesner, R. H., Krom, R. A. F., Atkinson, B., & Cortese, D. (1992). A prospective study of pulmonary function and gas exchange following liver transplantation. Chest, 102(4), 1161-1166.

A prospective study of pulmonary function and gas exchange following liver transplantation. / Krowka, M. J.; Dickson, E. R.; Wiesner, R. H.; Krom, R. A F; Atkinson, B.; Cortese, Denis.

In: Chest, Vol. 102, No. 4, 1992, p. 1161-1166.

Research output: Contribution to journalArticle

Krowka, MJ, Dickson, ER, Wiesner, RH, Krom, RAF, Atkinson, B & Cortese, D 1992, 'A prospective study of pulmonary function and gas exchange following liver transplantation', Chest, vol. 102, no. 4, pp. 1161-1166.
Krowka MJ, Dickson ER, Wiesner RH, Krom RAF, Atkinson B, Cortese D. A prospective study of pulmonary function and gas exchange following liver transplantation. Chest. 1992;102(4):1161-1166.
Krowka, M. J. ; Dickson, E. R. ; Wiesner, R. H. ; Krom, R. A F ; Atkinson, B. ; Cortese, Denis. / A prospective study of pulmonary function and gas exchange following liver transplantation. In: Chest. 1992 ; Vol. 102, No. 4. pp. 1161-1166.
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