A prospective study of pulmonary function and gas exchange following liver transplantation

M. J. Krowka, E. R. Dickson, R. H. Wiesner, R. A.F. Krom, B. Atkinson, D. A. Cortese

Research output: Contribution to journalArticle

35 Scopus citations


Pulmonary function and gas exchange were prospectively studied in 95 patients before and 9 to 15 months following liver transplantation. Pretransplant, the most common PF abnormality was impaired efficiency of gas exchange as measured by Dss. As a group, the mean Dss was 78.0 ± 16.6 percent predicted and was found to be less than 80 percent predicted in 50 patients. As a group, patients with the most severe liver diseases clinically (Child's C classification) had the lowest mean Dss pretransplant. Posttransplant, three findings were of clinical importance: PaCO2 significantly improved posttransplantation, suggesting a resolution of pretransplant respiratory alkalosis. Expiratory airflow obstruction, measured by a change in the FEV1/FVC, was extremely uncommon posttransplant. Mean Dss improved significantly in patients with Child's C severity of liver disease. The most frequent deteriorations in Dss statistically were associated with posttransplant thoracotomy, ARDS, nonspecific pneumonitis, significant pleural effusions and hepatic retransplantation.

Original languageEnglish (US)
Pages (from-to)1161-1166
Number of pages6
Issue number4
StatePublished - Jan 1 1992
Externally publishedYes


ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Krowka, M. J., Dickson, E. R., Wiesner, R. H., Krom, R. A. F., Atkinson, B., & Cortese, D. A. (1992). A prospective study of pulmonary function and gas exchange following liver transplantation. Chest, 102(4), 1161-1166. https://doi.org/10.1378/chest.102.4.1161