A prospective study of fasting plasma glucose and risk of stroke in asymptomatic men

Xuemei Sui, Carl J. Lavie, Steven P. Hooker, Duck Chul Lee, Natalie Colabianchi, Chong Lee, Steven N. Blair

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

OBJECTIVE: To examine the association between levels of fasting plasma glucose (FPG) and incidence of stroke outcomes in a large cohort of asymptomatic men. PATIENTS AND METHODS: Participants were 43,933 men (mean ± SD age, 44.3±9.9 years) who were free of known cardiovascular disease at baseline and whose FPG levels were assessed during a preventive medical examination at the Cooper Clinic, Dallas, TX, between January 7, 1971, and March 11, 2002. Patients with diagnosed diabetes mellitus (DM) or low FPG (<80 mg/dL [to convert to mmol/L, multiply by 0.0555]) were excluded. Fatal stroke was identified through the National Death Index, and nonfatal stroke was ascertained from mail-back surveys. RESULTS: A total of 595 stroke events (156 fatal and 456 nonfatal strokes; 17 men reported a nonfatal stroke before they died of stroke) occurred during 702,928 person-years of exposure. Ageadjusted fatal, nonfatal, and total stroke event rates per 10,000 person-years for normal FPG (80-109 mg/dL), impaired fasting glucose (110-125 mg/dL), and undiagnosed DM (≥126 mg/dL) were 2.1, 3.4, and 4.0 (Ptrend=.002); 10.3, 11.8, and 18.0 (Ptrend=.008); and 8.2, 9.6, and 12.4 (Ptrend=.008), respectively. After further adjusting for potential confounders, the direct association between FPG and fatal, nonfatal, or total stroke events remained significant (Ptrend=.02, .03, and .01, respectively). For FPG levels of 110 mg/dL or greater, each 10-unit increment of FPG was associated with a 6% higher risk of total stroke events (P=.05). CONCLUSION: Hyperglycemia (FPG, ≥110 mg/dL), even below the DM threshold (such as with impaired fasting glucose), was associated with a higher risk of fatal, nonfatal, or total stroke events in asymptomatic men.

Original languageEnglish (US)
Pages (from-to)1042-1049
Number of pages8
JournalMayo Clinic Proceedings
Volume86
Issue number11
DOIs
StatePublished - 2011

Fingerprint

Fasting
Stroke
Prospective Studies
Glucose
Diabetes Mellitus
Postal Service
Hyperglycemia
Cardiovascular Diseases
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sui, X., Lavie, C. J., Hooker, S. P., Lee, D. C., Colabianchi, N., Lee, C., & Blair, S. N. (2011). A prospective study of fasting plasma glucose and risk of stroke in asymptomatic men. Mayo Clinic Proceedings, 86(11), 1042-1049. https://doi.org/10.4065/mcp.2011.0267

A prospective study of fasting plasma glucose and risk of stroke in asymptomatic men. / Sui, Xuemei; Lavie, Carl J.; Hooker, Steven P.; Lee, Duck Chul; Colabianchi, Natalie; Lee, Chong; Blair, Steven N.

In: Mayo Clinic Proceedings, Vol. 86, No. 11, 2011, p. 1042-1049.

Research output: Contribution to journalArticle

Sui, X, Lavie, CJ, Hooker, SP, Lee, DC, Colabianchi, N, Lee, C & Blair, SN 2011, 'A prospective study of fasting plasma glucose and risk of stroke in asymptomatic men', Mayo Clinic Proceedings, vol. 86, no. 11, pp. 1042-1049. https://doi.org/10.4065/mcp.2011.0267
Sui, Xuemei ; Lavie, Carl J. ; Hooker, Steven P. ; Lee, Duck Chul ; Colabianchi, Natalie ; Lee, Chong ; Blair, Steven N. / A prospective study of fasting plasma glucose and risk of stroke in asymptomatic men. In: Mayo Clinic Proceedings. 2011 ; Vol. 86, No. 11. pp. 1042-1049.
@article{4cea949c61424fb588a832b2985d2104,
title = "A prospective study of fasting plasma glucose and risk of stroke in asymptomatic men",
abstract = "OBJECTIVE: To examine the association between levels of fasting plasma glucose (FPG) and incidence of stroke outcomes in a large cohort of asymptomatic men. PATIENTS AND METHODS: Participants were 43,933 men (mean ± SD age, 44.3±9.9 years) who were free of known cardiovascular disease at baseline and whose FPG levels were assessed during a preventive medical examination at the Cooper Clinic, Dallas, TX, between January 7, 1971, and March 11, 2002. Patients with diagnosed diabetes mellitus (DM) or low FPG (<80 mg/dL [to convert to mmol/L, multiply by 0.0555]) were excluded. Fatal stroke was identified through the National Death Index, and nonfatal stroke was ascertained from mail-back surveys. RESULTS: A total of 595 stroke events (156 fatal and 456 nonfatal strokes; 17 men reported a nonfatal stroke before they died of stroke) occurred during 702,928 person-years of exposure. Ageadjusted fatal, nonfatal, and total stroke event rates per 10,000 person-years for normal FPG (80-109 mg/dL), impaired fasting glucose (110-125 mg/dL), and undiagnosed DM (≥126 mg/dL) were 2.1, 3.4, and 4.0 (Ptrend=.002); 10.3, 11.8, and 18.0 (Ptrend=.008); and 8.2, 9.6, and 12.4 (Ptrend=.008), respectively. After further adjusting for potential confounders, the direct association between FPG and fatal, nonfatal, or total stroke events remained significant (Ptrend=.02, .03, and .01, respectively). For FPG levels of 110 mg/dL or greater, each 10-unit increment of FPG was associated with a 6{\%} higher risk of total stroke events (P=.05). CONCLUSION: Hyperglycemia (FPG, ≥110 mg/dL), even below the DM threshold (such as with impaired fasting glucose), was associated with a higher risk of fatal, nonfatal, or total stroke events in asymptomatic men.",
author = "Xuemei Sui and Lavie, {Carl J.} and Hooker, {Steven P.} and Lee, {Duck Chul} and Natalie Colabianchi and Chong Lee and Blair, {Steven N.}",
year = "2011",
doi = "10.4065/mcp.2011.0267",
language = "English (US)",
volume = "86",
pages = "1042--1049",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "11",

}

TY - JOUR

T1 - A prospective study of fasting plasma glucose and risk of stroke in asymptomatic men

AU - Sui, Xuemei

AU - Lavie, Carl J.

AU - Hooker, Steven P.

AU - Lee, Duck Chul

AU - Colabianchi, Natalie

AU - Lee, Chong

AU - Blair, Steven N.

PY - 2011

Y1 - 2011

N2 - OBJECTIVE: To examine the association between levels of fasting plasma glucose (FPG) and incidence of stroke outcomes in a large cohort of asymptomatic men. PATIENTS AND METHODS: Participants were 43,933 men (mean ± SD age, 44.3±9.9 years) who were free of known cardiovascular disease at baseline and whose FPG levels were assessed during a preventive medical examination at the Cooper Clinic, Dallas, TX, between January 7, 1971, and March 11, 2002. Patients with diagnosed diabetes mellitus (DM) or low FPG (<80 mg/dL [to convert to mmol/L, multiply by 0.0555]) were excluded. Fatal stroke was identified through the National Death Index, and nonfatal stroke was ascertained from mail-back surveys. RESULTS: A total of 595 stroke events (156 fatal and 456 nonfatal strokes; 17 men reported a nonfatal stroke before they died of stroke) occurred during 702,928 person-years of exposure. Ageadjusted fatal, nonfatal, and total stroke event rates per 10,000 person-years for normal FPG (80-109 mg/dL), impaired fasting glucose (110-125 mg/dL), and undiagnosed DM (≥126 mg/dL) were 2.1, 3.4, and 4.0 (Ptrend=.002); 10.3, 11.8, and 18.0 (Ptrend=.008); and 8.2, 9.6, and 12.4 (Ptrend=.008), respectively. After further adjusting for potential confounders, the direct association between FPG and fatal, nonfatal, or total stroke events remained significant (Ptrend=.02, .03, and .01, respectively). For FPG levels of 110 mg/dL or greater, each 10-unit increment of FPG was associated with a 6% higher risk of total stroke events (P=.05). CONCLUSION: Hyperglycemia (FPG, ≥110 mg/dL), even below the DM threshold (such as with impaired fasting glucose), was associated with a higher risk of fatal, nonfatal, or total stroke events in asymptomatic men.

AB - OBJECTIVE: To examine the association between levels of fasting plasma glucose (FPG) and incidence of stroke outcomes in a large cohort of asymptomatic men. PATIENTS AND METHODS: Participants were 43,933 men (mean ± SD age, 44.3±9.9 years) who were free of known cardiovascular disease at baseline and whose FPG levels were assessed during a preventive medical examination at the Cooper Clinic, Dallas, TX, between January 7, 1971, and March 11, 2002. Patients with diagnosed diabetes mellitus (DM) or low FPG (<80 mg/dL [to convert to mmol/L, multiply by 0.0555]) were excluded. Fatal stroke was identified through the National Death Index, and nonfatal stroke was ascertained from mail-back surveys. RESULTS: A total of 595 stroke events (156 fatal and 456 nonfatal strokes; 17 men reported a nonfatal stroke before they died of stroke) occurred during 702,928 person-years of exposure. Ageadjusted fatal, nonfatal, and total stroke event rates per 10,000 person-years for normal FPG (80-109 mg/dL), impaired fasting glucose (110-125 mg/dL), and undiagnosed DM (≥126 mg/dL) were 2.1, 3.4, and 4.0 (Ptrend=.002); 10.3, 11.8, and 18.0 (Ptrend=.008); and 8.2, 9.6, and 12.4 (Ptrend=.008), respectively. After further adjusting for potential confounders, the direct association between FPG and fatal, nonfatal, or total stroke events remained significant (Ptrend=.02, .03, and .01, respectively). For FPG levels of 110 mg/dL or greater, each 10-unit increment of FPG was associated with a 6% higher risk of total stroke events (P=.05). CONCLUSION: Hyperglycemia (FPG, ≥110 mg/dL), even below the DM threshold (such as with impaired fasting glucose), was associated with a higher risk of fatal, nonfatal, or total stroke events in asymptomatic men.

UR - http://www.scopus.com/inward/record.url?scp=80055078579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80055078579&partnerID=8YFLogxK

U2 - 10.4065/mcp.2011.0267

DO - 10.4065/mcp.2011.0267

M3 - Article

C2 - 21911559

AN - SCOPUS:80055078579

VL - 86

SP - 1042

EP - 1049

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 11

ER -