A point of care electrochemical impedance spectroscopy device

Zhijian Lu; Hongyi Wang; Syed Roomi Naqvi; Houqiang Fu; Yuji Zhao; Hongjiang Song; Jennifer Blain Christen

doi:10.1109/SOCC.2015.7406955

A point of care electrochemical impedance spectroscopy device

Zhijian Lu, Hongyi Wang, Syed Roomi Naqvi, Houqiang Fu, Yuji Zhao, Hongjiang Song, Jennifer Blain Christen

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

6 Scopus citations

Abstract

Electrochemical Impedance Spectroscopy (EIS) is a label-free method of molecular detection of particular interest for biomedical applications. We aim to create a hand-held, easy to use EIS measurement device, for biomolecular detection. Electrochemical cyclic voltammetry systems help millions of diabetics monitor their blood glucose levels 2-8 times per day, but their use is very limited due to the poor lower limit of detection. The EIS technique can be used to detect a much larger array of biomolecules at very low concentration. Our EIS system generates the magnitude and phase of the impedance from test samples via MATLAB, which provides the real and imaginary components of the impedance. The circuit was integrated on a single chip and fabricated in a standard 0.5 μm CMOS technology. A hand-held EIS measurement system was built using the chip and an Arduino Uno to measure a Randles circuit equivalent over the frequency range from 1 Hz to 2 kHz, the measurement and simulation results show excellent agreement.

Original language	English (US)
Title of host publication	Proceedings - 28th IEEE International System on Chip Conference, SOCC 2015
Editors	Thomas Buchner, Danella Zhao, Karan Bhatia, Ramalingam Sridhar
Publisher	IEEE Computer Society
Pages	240-244
Number of pages	5
ISBN (Electronic)	9781467390934
DOIs	https://doi.org/10.1109/SOCC.2015.7406955
State	Published - Feb 12 2016
Event	28th IEEE International System on Chip Conference, SOCC 2015 - Beijing, China Duration: Sep 8 2015 → Sep 11 2015

Publication series

Name	International System on Chip Conference
Volume	2016-February
ISSN (Print)	2164-1676
ISSN (Electronic)	2164-1706

Other

Other	28th IEEE International System on Chip Conference, SOCC 2015
Country/Territory	China
City	Beijing
Period	9/8/15 → 9/11/15

Keywords

Arduino Uno
CMOS
Digital to Analog Converter
Electrochemical Impedance Spectroscopy
Hand-held
Magnitude Phase Measurement
Operational Amplifier
Point of Care

ASJC Scopus subject areas

Hardware and Architecture
Control and Systems Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/SOCC.2015.7406955

Cite this

Lu, Z., Wang, H., Naqvi, S. R., Fu, H., Zhao, Y., Song, H., & Blain Christen, J. (2016). A point of care electrochemical impedance spectroscopy device. In T. Buchner, D. Zhao, K. Bhatia, & R. Sridhar (Eds.), Proceedings - 28th IEEE International System on Chip Conference, SOCC 2015 (pp. 240-244). Article 7406955 (International System on Chip Conference; Vol. 2016-February). IEEE Computer Society. https://doi.org/10.1109/SOCC.2015.7406955

A point of care electrochemical impedance spectroscopy device. / Lu, Zhijian; Wang, Hongyi; Naqvi, Syed Roomi et al.
Proceedings - 28th IEEE International System on Chip Conference, SOCC 2015. ed. / Thomas Buchner; Danella Zhao; Karan Bhatia; Ramalingam Sridhar. IEEE Computer Society, 2016. p. 240-244 7406955 (International System on Chip Conference; Vol. 2016-February).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Lu, Z, Wang, H, Naqvi, SR, Fu, H, Zhao, Y, Song, H & Blain Christen, J 2016, A point of care electrochemical impedance spectroscopy device. in T Buchner, D Zhao, K Bhatia & R Sridhar (eds), Proceedings - 28th IEEE International System on Chip Conference, SOCC 2015., 7406955, International System on Chip Conference, vol. 2016-February, IEEE Computer Society, pp. 240-244, 28th IEEE International System on Chip Conference, SOCC 2015, Beijing, China, 9/8/15. https://doi.org/10.1109/SOCC.2015.7406955

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abstract = "Electrochemical Impedance Spectroscopy (EIS) is a label-free method of molecular detection of particular interest for biomedical applications. We aim to create a hand-held, easy to use EIS measurement device, for biomolecular detection. Electrochemical cyclic voltammetry systems help millions of diabetics monitor their blood glucose levels 2-8 times per day, but their use is very limited due to the poor lower limit of detection. The EIS technique can be used to detect a much larger array of biomolecules at very low concentration. Our EIS system generates the magnitude and phase of the impedance from test samples via MATLAB, which provides the real and imaginary components of the impedance. The circuit was integrated on a single chip and fabricated in a standard 0.5 μm CMOS technology. A hand-held EIS measurement system was built using the chip and an Arduino Uno to measure a Randles circuit equivalent over the frequency range from 1 Hz to 2 kHz, the measurement and simulation results show excellent agreement.",

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AB - Electrochemical Impedance Spectroscopy (EIS) is a label-free method of molecular detection of particular interest for biomedical applications. We aim to create a hand-held, easy to use EIS measurement device, for biomolecular detection. Electrochemical cyclic voltammetry systems help millions of diabetics monitor their blood glucose levels 2-8 times per day, but their use is very limited due to the poor lower limit of detection. The EIS technique can be used to detect a much larger array of biomolecules at very low concentration. Our EIS system generates the magnitude and phase of the impedance from test samples via MATLAB, which provides the real and imaginary components of the impedance. The circuit was integrated on a single chip and fabricated in a standard 0.5 μm CMOS technology. A hand-held EIS measurement system was built using the chip and an Arduino Uno to measure a Randles circuit equivalent over the frequency range from 1 Hz to 2 kHz, the measurement and simulation results show excellent agreement.

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A point of care electrochemical impedance spectroscopy device

Abstract

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Keywords

ASJC Scopus subject areas

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