A point of care electrochemical impedance spectroscopy device

Zhijian Lu, Hongyi Wang, Syed Roomi Naqvi, Houqiang Fu, Yuji Zhao, Hongjiang Song, Jennifer Blain Christen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Electrochemical Impedance Spectroscopy (EIS) is a label-free method of molecular detection of particular interest for biomedical applications. We aim to create a hand-held, easy to use EIS measurement device, for biomolecular detection. Electrochemical cyclic voltammetry systems help millions of diabetics monitor their blood glucose levels 2-8 times per day, but their use is very limited due to the poor lower limit of detection. The EIS technique can be used to detect a much larger array of biomolecules at very low concentration. Our EIS system generates the magnitude and phase of the impedance from test samples via MATLAB, which provides the real and imaginary components of the impedance. The circuit was integrated on a single chip and fabricated in a standard 0.5 μm CMOS technology. A hand-held EIS measurement system was built using the chip and an Arduino Uno to measure a Randles circuit equivalent over the frequency range from 1 Hz to 2 kHz, the measurement and simulation results show excellent agreement.

Original languageEnglish (US)
Title of host publicationProceedings - 28th IEEE International System on Chip Conference, SOCC 2015
EditorsThomas Buchner, Danella Zhao, Karan Bhatia, Ramalingam Sridhar
PublisherIEEE Computer Society
Pages240-244
Number of pages5
ISBN (Electronic)9781467390934
DOIs
StatePublished - Feb 12 2016
Event28th IEEE International System on Chip Conference, SOCC 2015 - Beijing, China
Duration: Sep 8 2015Sep 11 2015

Publication series

NameInternational System on Chip Conference
Volume2016-February
ISSN (Print)2164-1676
ISSN (Electronic)2164-1706

Other

Other28th IEEE International System on Chip Conference, SOCC 2015
CountryChina
CityBeijing
Period9/8/159/11/15

Keywords

  • Arduino Uno
  • CMOS
  • Digital to Analog Converter
  • Electrochemical Impedance Spectroscopy
  • Hand-held
  • Magnitude Phase Measurement
  • Operational Amplifier
  • Point of Care

ASJC Scopus subject areas

  • Hardware and Architecture
  • Control and Systems Engineering
  • Electrical and Electronic Engineering

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  • Cite this

    Lu, Z., Wang, H., Naqvi, S. R., Fu, H., Zhao, Y., Song, H., & Blain Christen, J. (2016). A point of care electrochemical impedance spectroscopy device. In T. Buchner, D. Zhao, K. Bhatia, & R. Sridhar (Eds.), Proceedings - 28th IEEE International System on Chip Conference, SOCC 2015 (pp. 240-244). [7406955] (International System on Chip Conference; Vol. 2016-February). IEEE Computer Society. https://doi.org/10.1109/SOCC.2015.7406955