A pathway and genetic factors contributing to elevated gene expression noise in stationary phase

Nicholas J. Guido, Philina Lee, Xiao Wang, Timothy C. Elston, J. J. Collins

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Previous studies have identified factors associated with transcription and translation efficiency, such as promoter strength and mRNA sequences, that can affect stochasticity in gene expression. Here we present evidence for a pathway and associated genetic factors (namely, the ribosome modulation factor RMF and ppGpp) in Escherichia coli that contribute to heightened levels of gene expression noise during stationary phase. Endogenous cellular mechanisms that globally affect gene expression noise, such as those identified in this study, could provide phenotypic diversity under adverse conditions such as stationary phase.

Original languageEnglish (US)
JournalBiophysical Journal
Volume93
Issue number11
DOIs
StatePublished - Dec 1 2007
Externally publishedYes

Fingerprint

Noise
Gene Expression
Ribosomes
Escherichia coli
Messenger RNA

ASJC Scopus subject areas

  • Biophysics

Cite this

A pathway and genetic factors contributing to elevated gene expression noise in stationary phase. / Guido, Nicholas J.; Lee, Philina; Wang, Xiao; Elston, Timothy C.; Collins, J. J.

In: Biophysical Journal, Vol. 93, No. 11, 01.12.2007.

Research output: Contribution to journalArticle

Guido, Nicholas J. ; Lee, Philina ; Wang, Xiao ; Elston, Timothy C. ; Collins, J. J. / A pathway and genetic factors contributing to elevated gene expression noise in stationary phase. In: Biophysical Journal. 2007 ; Vol. 93, No. 11.
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