A numerical algorithm for investigating the role of the motor-cargo linkage in molecular motor-driven transport

John Fricks, Hongyun Wang, Timothy C. Elston

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We extend the numerical algorithm developed by Wang et al. (2003. J. Theor. Biol. 221, 491-511) for studying biomolecular transport processes to include the linkage that connects molecular motors to their cargo. The new algorithm is used to investigate how the stiffness of the linkage affects the average velocity, effective diffusion coefficient, and randomness parameter. Three different models for molecular motors are considered: (1) a discrete stepping motor (2) a motor moving in a tilted-periodic potential and (3) a motor driven by a flashing potential. We demonstrate that a flexible motor-cargo linkage can make inferences on motor behavior based on measurements of the cargo's position difficult. We also show that even for the case of a tilted-periodic potential there exists an optimal stiffness of the linkage at which transport is maximized. The MATLAB code used in this paper is available at: http://www.unc.edu/̃telston/code/.

Original languageEnglish (US)
Pages (from-to)33-48
Number of pages16
JournalJournal of Theoretical Biology
Volume239
Issue number1
DOIs
StatePublished - Mar 7 2006
Externally publishedYes

Fingerprint

Molecular Motor
Numerical Algorithms
Linkage
Molecular Models
Periodic Potential
Stiffness
Transport Processes
Stepping motors
Randomness
Diffusion Coefficient
MATLAB
molecular models
diffusivity
Demonstrate

Keywords

  • Markov chain
  • Molecular motors
  • Numerical method
  • Stochastic process

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

A numerical algorithm for investigating the role of the motor-cargo linkage in molecular motor-driven transport. / Fricks, John; Wang, Hongyun; Elston, Timothy C.

In: Journal of Theoretical Biology, Vol. 239, No. 1, 07.03.2006, p. 33-48.

Research output: Contribution to journalArticle

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