A novel member of the serpin superfamily is encoded on a circular plasmid-like DNA species isolated from rabbit cells

C. Upton, R. W. Carrell, G. McFadden

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A novel member of the serpin family of serine protease inhibitors is presented. A plasmid-like DNA was isolated from rabbit cells by its homology to the genome of Shope fibroma virus (SFV), a tumorigenic poxvirus of rabbits, and was shown elsewhere to encode a serpin-like protein [(1986) Mol. Cell. Biol. 6, 265-276]. Although significant DNA homology exists between the rabbit plasmid serpin open reading frame and the SFV terminal inverted repeat DNA there is no intact serpin counterpart encoded by this region of the SFV genome. The alignment of the novel plasmid-borne polypeptide with the serpin family of proteins confirms its status within this group.

Original languageEnglish (US)
Pages (from-to)115-120
Number of pages6
JournalFEBS Letters
Volume207
Issue number1
DOIs
StatePublished - Oct 20 1986
Externally publishedYes

Keywords

  • Poxvirus
  • Serine protease inhibitor
  • Serpin
  • Shope fibroma virus
  • spc DNA

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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