A novel member of the serpin superfamily is encoded on a circular plasmid-like DNA species isolated from rabbit cells

C. Upton; R. W. Carrell; G. McFadden

doi:10.1016/0014-5793(86)80023-0

A novel member of the serpin superfamily is encoded on a circular plasmid-like DNA species isolated from rabbit cells

C. Upton, R. W. Carrell, G. McFadden

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10 Scopus citations

Abstract

A novel member of the serpin family of serine protease inhibitors is presented. A plasmid-like DNA was isolated from rabbit cells by its homology to the genome of Shope fibroma virus (SFV), a tumorigenic poxvirus of rabbits, and was shown elsewhere to encode a serpin-like protein [(1986) Mol. Cell. Biol. 6, 265-276]. Although significant DNA homology exists between the rabbit plasmid serpin open reading frame and the SFV terminal inverted repeat DNA there is no intact serpin counterpart encoded by this region of the SFV genome. The alignment of the novel plasmid-borne polypeptide with the serpin family of proteins confirms its status within this group.

Original language	English (US)
Pages (from-to)	115-120
Number of pages	6
Journal	FEBS Letters
Volume	207
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(86)80023-0
State	Published - Oct 20 1986
Externally published	Yes

Keywords

Poxvirus
Serine protease inhibitor
Serpin
Shope fibroma virus
spc DNA

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(86)80023-0

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title = "A novel member of the serpin superfamily is encoded on a circular plasmid-like DNA species isolated from rabbit cells",

abstract = "A novel member of the serpin family of serine protease inhibitors is presented. A plasmid-like DNA was isolated from rabbit cells by its homology to the genome of Shope fibroma virus (SFV), a tumorigenic poxvirus of rabbits, and was shown elsewhere to encode a serpin-like protein [(1986) Mol. Cell. Biol. 6, 265-276]. Although significant DNA homology exists between the rabbit plasmid serpin open reading frame and the SFV terminal inverted repeat DNA there is no intact serpin counterpart encoded by this region of the SFV genome. The alignment of the novel plasmid-borne polypeptide with the serpin family of proteins confirms its status within this group.",

keywords = "Poxvirus, Serine protease inhibitor, Serpin, Shope fibroma virus, spc DNA",

author = "C. Upton and Carrell, {R. W.} and G. McFadden",

note = "Funding Information: This work was supported by the Alberta Heritage Foundation for Medical Research (AHFMR), the National Cancer Institute of Canadaa nd the Alberta Cancer Board. Computer costs of the BIONET resource were funded by Public Health Service grant l-441-RR0168501 from the National Instituteso f Health. G.M. is an AHFMR scholar and C.U. a postdoctoralf ellow. R.W.C. was supportedb y the Medical Research Council of New Zealand.",

year = "1986",

month = oct,

day = "20",

doi = "10.1016/0014-5793(86)80023-0",

language = "English (US)",

volume = "207",

pages = "115--120",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Elsevier",

number = "1",

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TY - JOUR

T1 - A novel member of the serpin superfamily is encoded on a circular plasmid-like DNA species isolated from rabbit cells

AU - Upton, C.

AU - Carrell, R. W.

AU - McFadden, G.

N1 - Funding Information: This work was supported by the Alberta Heritage Foundation for Medical Research (AHFMR), the National Cancer Institute of Canadaa nd the Alberta Cancer Board. Computer costs of the BIONET resource were funded by Public Health Service grant l-441-RR0168501 from the National Instituteso f Health. G.M. is an AHFMR scholar and C.U. a postdoctoralf ellow. R.W.C. was supportedb y the Medical Research Council of New Zealand.

PY - 1986/10/20

Y1 - 1986/10/20

N2 - A novel member of the serpin family of serine protease inhibitors is presented. A plasmid-like DNA was isolated from rabbit cells by its homology to the genome of Shope fibroma virus (SFV), a tumorigenic poxvirus of rabbits, and was shown elsewhere to encode a serpin-like protein [(1986) Mol. Cell. Biol. 6, 265-276]. Although significant DNA homology exists between the rabbit plasmid serpin open reading frame and the SFV terminal inverted repeat DNA there is no intact serpin counterpart encoded by this region of the SFV genome. The alignment of the novel plasmid-borne polypeptide with the serpin family of proteins confirms its status within this group.

AB - A novel member of the serpin family of serine protease inhibitors is presented. A plasmid-like DNA was isolated from rabbit cells by its homology to the genome of Shope fibroma virus (SFV), a tumorigenic poxvirus of rabbits, and was shown elsewhere to encode a serpin-like protein [(1986) Mol. Cell. Biol. 6, 265-276]. Although significant DNA homology exists between the rabbit plasmid serpin open reading frame and the SFV terminal inverted repeat DNA there is no intact serpin counterpart encoded by this region of the SFV genome. The alignment of the novel plasmid-borne polypeptide with the serpin family of proteins confirms its status within this group.

KW - Poxvirus

KW - Serine protease inhibitor

KW - Serpin

KW - Shope fibroma virus

KW - spc DNA

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DO - 10.1016/0014-5793(86)80023-0

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AN - SCOPUS:0022967916

SN - 0014-5793

VL - 207

SP - 115

EP - 120

JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -

A novel member of the serpin superfamily is encoded on a circular plasmid-like DNA species isolated from rabbit cells

Abstract

Keywords

ASJC Scopus subject areas

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