A nonproducer T lymphoblastoid cell line from Marek's disease transplantable tumor (JMV).

K. Nazerian, E. A. Stephens, J. M. Sharma, L. F. Lee, M. Gailitis, R. L. Witter

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Abstract

A continuous lymphoblastoid cell line was established from a JMV tumor transplant related to Marek's disease (MD). It is designated RPL1 (JMV) lymphoblastoid cell line. This cell line contains DNA sequences complementary to MD virus DNA and has an antigen similar to MD-tumor-associated surface antigen (MATSA). However, it lacks any MD virus (MDV) rescuable in vivo or in vitro. The cell line has surface antigens typical of chicken thymus cells (T cells) and histocompatability antigens different from those of the host chicken.

Original languageEnglish (US)
Pages (from-to)69-76
Number of pages8
JournalAvian diseases
Volume21
Issue number1
DOIs
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology
  • Immunology and Microbiology(all)

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    Nazerian, K., Stephens, E. A., Sharma, J. M., Lee, L. F., Gailitis, M., & Witter, R. L. (1977). A nonproducer T lymphoblastoid cell line from Marek's disease transplantable tumor (JMV). Avian diseases, 21(1), 69-76. https://doi.org/10.2307/1589365