A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase β lyase

V. S.Prakash Chaturvedula, Zhijie Gao, Shannon H. Jones, Xizhi Feng, Sidney M. Hecht, David G.I. Kingston

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Bioassay-directed fractionation of a butanone extract of Monochaetum vulcanicum resulted in the isolation of a new triterpene (1) and four known compounds, ursolic acid (2), 2α-hydroxyursolic acid (3), 3-(p-coumaroyl)ursolic acid (4), and β-sitosteryl-β-D-galactoside (5). The structure of the new compound 1 was established as 3β-acetoxy-2α -hydroxyurs-12-en-28-oic acid on the basis of extensive 1D and 2D NMR spectroscopic interpretation and chemical derivatization. Compounds 1-3 and 5 exhibited polymerase β lyase activity.

Original languageEnglish (US)
Pages (from-to)899-901
Number of pages3
JournalJournal of Natural Products
Volume67
Issue number5
DOIs
StatePublished - May 2004
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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