Abstract
Bioassay-directed fractionation of a butanone extract of Monochaetum vulcanicum resulted in the isolation of a new triterpene (1) and four known compounds, ursolic acid (2), 2α-hydroxyursolic acid (3), 3-(p-coumaroyl)ursolic acid (4), and β-sitosteryl-β-D-galactoside (5). The structure of the new compound 1 was established as 3β-acetoxy-2α -hydroxyurs-12-en-28-oic acid on the basis of extensive 1D and 2D NMR spectroscopic interpretation and chemical derivatization. Compounds 1-3 and 5 exhibited polymerase β lyase activity.
Original language | English (US) |
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Pages (from-to) | 899-901 |
Number of pages | 3 |
Journal | Journal of Natural Products |
Volume | 67 |
Issue number | 5 |
DOIs | |
State | Published - May 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry