A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase β lyase

V. S Prakash Chaturvedula, Zhijie Gao, Shannon H. Jones, Xizhi Feng, Sidney Hecht, David G I Kingston

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Bioassay-directed fractionation of a butanone extract of Monochaetum vulcanicum resulted in the isolation of a new triterpene (1) and four known compounds, ursolic acid (2), 2α-hydroxyursolic acid (3), 3-(p-coumaroyl)ursolic acid (4), and β-sitosteryl-β-D-galactoside (5). The structure of the new compound 1 was established as 3β-acetoxy-2α -hydroxyurs-12-en-28-oic acid on the basis of extensive 1D and 2D NMR spectroscopic interpretation and chemical derivatization. Compounds 1-3 and 5 exhibited polymerase β lyase activity.

Original languageEnglish (US)
Pages (from-to)899-901
Number of pages3
JournalJournal of Natural Products
Volume67
Issue number5
DOIs
StatePublished - May 2004
Externally publishedYes

Fingerprint

ursolic acid
Triterpenes
Lyases
lyases
DNA-directed DNA polymerase
DNA-Directed DNA Polymerase
triterpenoids
Butanones
Galactosides
galactosides
Bioassay
acids
derivatization
Fractionation
Biological Assay
fractionation
bioassays
Nuclear magnetic resonance
Acids
extracts

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase β lyase. / Chaturvedula, V. S Prakash; Gao, Zhijie; Jones, Shannon H.; Feng, Xizhi; Hecht, Sidney; Kingston, David G I.

In: Journal of Natural Products, Vol. 67, No. 5, 05.2004, p. 899-901.

Research output: Contribution to journalArticle

Chaturvedula, V. S Prakash ; Gao, Zhijie ; Jones, Shannon H. ; Feng, Xizhi ; Hecht, Sidney ; Kingston, David G I. / A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase β lyase. In: Journal of Natural Products. 2004 ; Vol. 67, No. 5. pp. 899-901.
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