A new era for electron bifurcation

John W. Peters, David N. Beratan, Brian Bothner, R. Brian Dyer, Caroline S. Harwood, Zachariah M. Heiden, Russ Hille, Anne Jones, Paul W. King, Yi Lu, Carolyn E. Lubner, Shelley D. Minteer, David W. Mulder, Simone Raugei, Gerrit J. Schut, Lance C. Seefeldt, Monika Tokmina-Lukaszewska, Oleg A. Zadvornyy, Peng Zhang, Michael WW Adams

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Electron bifurcation, or the coupling of exergonic and endergonic oxidation-reduction reactions, was discovered by Peter Mitchell and provides an elegant mechanism to rationalize and understand the logic that underpins the Q cycle of the respiratory chain. Thought to be a unique reaction of respiratory complex III for nearly 40 years, about a decade ago Wolfgang Buckel and Rudolf Thauer discovered that flavin-based electron bifurcation is also an important component of anaerobic microbial metabolism. Their discovery spawned a surge of research activity, providing a basis to understand flavin-based bifurcation, forging fundamental parallels with Mitchell's Q cycle and leading to the proposal of metal-based bifurcating enzymes. New insights into the mechanism of electron bifurcation provide a foundation to establish the unifying principles and essential elements of this fascinating biochemical phenomenon.

Original languageEnglish (US)
Pages (from-to)32-38
Number of pages7
JournalCurrent Opinion in Chemical Biology
Volume47
DOIs
StatePublished - Dec 1 2018

Fingerprint

Electrons
Biochemical Phenomena
Anaerobiosis
Electron Transport Complex III
Redox reactions
Electron Transport
Forging
Metabolism
Oxidation-Reduction
Metals
Enzymes
Research
4,6-dinitro-o-cresol

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

Cite this

Peters, J. W., Beratan, D. N., Bothner, B., Dyer, R. B., Harwood, C. S., Heiden, Z. M., ... Adams, M. WW. (2018). A new era for electron bifurcation. Current Opinion in Chemical Biology, 47, 32-38. https://doi.org/10.1016/j.cbpa.2018.07.026

A new era for electron bifurcation. / Peters, John W.; Beratan, David N.; Bothner, Brian; Dyer, R. Brian; Harwood, Caroline S.; Heiden, Zachariah M.; Hille, Russ; Jones, Anne; King, Paul W.; Lu, Yi; Lubner, Carolyn E.; Minteer, Shelley D.; Mulder, David W.; Raugei, Simone; Schut, Gerrit J.; Seefeldt, Lance C.; Tokmina-Lukaszewska, Monika; Zadvornyy, Oleg A.; Zhang, Peng; Adams, Michael WW.

In: Current Opinion in Chemical Biology, Vol. 47, 01.12.2018, p. 32-38.

Research output: Contribution to journalReview article

Peters, JW, Beratan, DN, Bothner, B, Dyer, RB, Harwood, CS, Heiden, ZM, Hille, R, Jones, A, King, PW, Lu, Y, Lubner, CE, Minteer, SD, Mulder, DW, Raugei, S, Schut, GJ, Seefeldt, LC, Tokmina-Lukaszewska, M, Zadvornyy, OA, Zhang, P & Adams, MWW 2018, 'A new era for electron bifurcation', Current Opinion in Chemical Biology, vol. 47, pp. 32-38. https://doi.org/10.1016/j.cbpa.2018.07.026
Peters JW, Beratan DN, Bothner B, Dyer RB, Harwood CS, Heiden ZM et al. A new era for electron bifurcation. Current Opinion in Chemical Biology. 2018 Dec 1;47:32-38. https://doi.org/10.1016/j.cbpa.2018.07.026
Peters, John W. ; Beratan, David N. ; Bothner, Brian ; Dyer, R. Brian ; Harwood, Caroline S. ; Heiden, Zachariah M. ; Hille, Russ ; Jones, Anne ; King, Paul W. ; Lu, Yi ; Lubner, Carolyn E. ; Minteer, Shelley D. ; Mulder, David W. ; Raugei, Simone ; Schut, Gerrit J. ; Seefeldt, Lance C. ; Tokmina-Lukaszewska, Monika ; Zadvornyy, Oleg A. ; Zhang, Peng ; Adams, Michael WW. / A new era for electron bifurcation. In: Current Opinion in Chemical Biology. 2018 ; Vol. 47. pp. 32-38.
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AU - Heiden, Zachariah M.

AU - Hille, Russ

AU - Jones, Anne

AU - King, Paul W.

AU - Lu, Yi

AU - Lubner, Carolyn E.

AU - Minteer, Shelley D.

AU - Mulder, David W.

AU - Raugei, Simone

AU - Schut, Gerrit J.

AU - Seefeldt, Lance C.

AU - Tokmina-Lukaszewska, Monika

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AU - Zhang, Peng

AU - Adams, Michael WW

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AB - Electron bifurcation, or the coupling of exergonic and endergonic oxidation-reduction reactions, was discovered by Peter Mitchell and provides an elegant mechanism to rationalize and understand the logic that underpins the Q cycle of the respiratory chain. Thought to be a unique reaction of respiratory complex III for nearly 40 years, about a decade ago Wolfgang Buckel and Rudolf Thauer discovered that flavin-based electron bifurcation is also an important component of anaerobic microbial metabolism. Their discovery spawned a surge of research activity, providing a basis to understand flavin-based bifurcation, forging fundamental parallels with Mitchell's Q cycle and leading to the proposal of metal-based bifurcating enzymes. New insights into the mechanism of electron bifurcation provide a foundation to establish the unifying principles and essential elements of this fascinating biochemical phenomenon.

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