A new cancer genome anatomy project web resource for the community

C. Schaefer, L. Grouse, K. Buetow, R. L. Strausberg

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

The National Cancer Institute's Cancer Genome Anatomy Project (CGAP) is developing publicly accessible information, technology, and material resources that provide a platform for the interface of cancer research and genomics. CGAP's efforts have focused toward (1) building and annotating catalogues of genes expressed during cancer development, (2) identifying polymorphisms in those genes, and (3) developing resources for the molecular characterization of cancer-related chromosomal aberrations. To date, CGAP has produced more than 1,000,000 expressed sequence tags, approximately 3,300,000 serial analysis of gene expression tags, and identified more than 10,000 human gene-based single-nucleotide polymorphisms. To enhance access to these datasets by the research community, a new Cancer Genome Project web site (http://cgap.nci.nih.gov/) is being introduced. The web site includes genomic data for humans and mice, including transcript sequence, gene expression patterns, single-nucleotide polymorphisms, clone resources, and cytogenetic information. Descriptions of the methods and reagents used in deriving the CGAP datasets are also provided. An extensive suite of informatics tools facilitates queries and analysis of the CGAP data by the community. One of the newest features of the CGAP web site is an electronic version of the Mitelman Database of Chromosome Aberrations in Cancer.

Original languageEnglish (US)
Pages (from-to)52-60
Number of pages9
JournalCancer Journal
Volume7
Issue number1
StatePublished - Mar 19 2001

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Keywords

  • Bacterial artificial chromosomes
  • Bioinformatics
  • Cancer
  • Chromosome aberrations
  • Expressed sequence tags
  • Gene discovery
  • Genomics
  • Molecular cytogenetics
  • SAGE
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Schaefer, C., Grouse, L., Buetow, K., & Strausberg, R. L. (2001). A new cancer genome anatomy project web resource for the community. Cancer Journal, 7(1), 52-60.