A new apparatus for serial crystallography at the Advanced Light Source

David Shapiro, R. Bruce Doak, John Spence, Dmitri Starodub, Uwe Weierstall, Henry Chapman

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We have designed and commissioned an apparatus for serial crystallography of hydrated proteins at the Advanced Light Source. Serial crystallography is a recently proposed method of imaging uncrystallized proteins at a third generation synchrotron source. This paper describes the design of the apparatus and results from the first experiment, which recorded x-ray diffraction patterns from 8 micron droplets containing photosystem 1 protein molecules.

Original languageEnglish (US)
Title of host publicationDevelopments in X-Ray Tomography V
StatePublished - Nov 13 2006
EventDevelopments in X-Ray Tomography V - San Diego, CA, United States
Duration: Aug 15 2006Aug 17 2006

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherDevelopments in X-Ray Tomography V
Country/TerritoryUnited States
CitySan Diego, CA


  • Crystallography
  • Serial crystallography
  • X-ray diffraction
  • X-ray diffraction imaging
  • X-ray microscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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