A new anti-tubulin agent containing the benzo[b]thiophene ring system

Kevin G. Pinney, A. Dawn Bounds, Koren M. Dingeman, Vani P. Mocharla, George Pettit, Ruoli Bai, Ernest Hamel

Research output: Contribution to journalArticle

114 Scopus citations

Abstract

A new type of inhibitor of tubulin polymerization was discovered based on the 3-aroyl-2-arylbenzo[b]thiophene molecular skeleton. The lead compound in this series, 2-(4'-methoxyphenyl)-3-(3',4',5'-trimethoxybenzoyl)-6- methoxybenzo[b]thiophene 1, inhibited tubulin polymerization, caused an increase in the mitotic index of CA46 Burkitt lymphoma cells, and inhibited the growth of several human cancer cell lines.

Original languageEnglish (US)
Pages (from-to)1081-1086
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number8
DOIs
StatePublished - Apr 19 1999

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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    Pinney, K. G., Bounds, A. D., Dingeman, K. M., Mocharla, V. P., Pettit, G., Bai, R., & Hamel, E. (1999). A new anti-tubulin agent containing the benzo[b]thiophene ring system. Bioorganic and Medicinal Chemistry Letters, 9(8), 1081-1086. https://doi.org/10.1016/S0960-894X(99)00143-2