A new anti-tubulin agent containing the benzo[b]thiophene ring system

Kevin G. Pinney; A. Dawn Bounds; Koren M. Dingeman; Vani P. Mocharla; George Pettit; Ruoli Bai; Ernest Hamel

doi:10.1016/S0960-894X(99)00143-2

A new anti-tubulin agent containing the benzo[b]thiophene ring system

Kevin G. Pinney, A. Dawn Bounds, Koren M. Dingeman, Vani P. Mocharla, George Pettit, Ruoli Bai, Ernest Hamel

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

A new type of inhibitor of tubulin polymerization was discovered based on the 3-aroyl-2-arylbenzo[b]thiophene molecular skeleton. The lead compound in this series, 2-(4'-methoxyphenyl)-3-(3',4',5'-trimethoxybenzoyl)-6- methoxybenzo[b]thiophene 1, inhibited tubulin polymerization, caused an increase in the mitotic index of CA46 Burkitt lymphoma cells, and inhibited the growth of several human cancer cell lines.

Original language	English (US)
Pages (from-to)	1081-1086
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	8
DOIs	https://doi.org/10.1016/S0960-894X(99)00143-2
State	Published - Apr 19 1999

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(99)00143-2

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title = "A new anti-tubulin agent containing the benzo[b]thiophene ring system",

abstract = "A new type of inhibitor of tubulin polymerization was discovered based on the 3-aroyl-2-arylbenzo[b]thiophene molecular skeleton. The lead compound in this series, 2-(4'-methoxyphenyl)-3-(3',4',5'-trimethoxybenzoyl)-6- methoxybenzo[b]thiophene 1, inhibited tubulin polymerization, caused an increase in the mitotic index of CA46 Burkitt lymphoma cells, and inhibited the growth of several human cancer cell lines.",

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AU - Pinney, Kevin G.

AU - Bounds, A. Dawn

AU - Dingeman, Koren M.

AU - Mocharla, Vani P.

AU - Pettit, George

AU - Bai, Ruoli

AU - Hamel, Ernest

PY - 1999/4/19

Y1 - 1999/4/19

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AB - A new type of inhibitor of tubulin polymerization was discovered based on the 3-aroyl-2-arylbenzo[b]thiophene molecular skeleton. The lead compound in this series, 2-(4'-methoxyphenyl)-3-(3',4',5'-trimethoxybenzoyl)-6- methoxybenzo[b]thiophene 1, inhibited tubulin polymerization, caused an increase in the mitotic index of CA46 Burkitt lymphoma cells, and inhibited the growth of several human cancer cell lines.

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EP - 1086

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

A new anti-tubulin agent containing the benzo[b]thiophene ring system

Abstract

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