A New Acylated Oleanane Triterpenoid from Couepia polyandra that Inhibits the Lyase Activity of DNA Polymerase β

V. S. Prakash Chaturvedula; Zhijie Gao; Sidney M. Hecht; Shannon H. Jones; David G.I. Kingston

doi:10.1021/np0301893

A New Acylated Oleanane Triterpenoid from Couepia polyandra that Inhibits the Lyase Activity of DNA Polymerase β

V. S. Prakash Chaturvedula, Zhijie Gao, Sidney M. Hecht, Shannon H. Jones, David G.I. Kingston

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Bioassay-directed fractionation of a n-hexane extract of Couepia polyandra using an assay to detect inhibitors of the lyase activity of DNA polymerase β resulted in the isolation of the new triterpene 3β,16β ,23-triacetoxyolean-12-en-28-oic acid (1) and four known compounds, oleanolic acid, betulinic acid, stigmasterol, and β-sitosterol. The structure of the new compound was established on the basis of extensive 1D and 2D NMR spectroscopic interpretation. All five compounds inhibited DNA polymerase β lyase activity.

Original language	English (US)
Pages (from-to)	1463-1465
Number of pages	3
Journal	Journal of Natural Products
Volume	66
Issue number	11
DOIs	https://doi.org/10.1021/np0301893
State	Published - Nov 2003
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "Bioassay-directed fractionation of a n-hexane extract of Couepia polyandra using an assay to detect inhibitors of the lyase activity of DNA polymerase β resulted in the isolation of the new triterpene 3β,16β ,23-triacetoxyolean-12-en-28-oic acid (1) and four known compounds, oleanolic acid, betulinic acid, stigmasterol, and β-sitosterol. The structure of the new compound was established on the basis of extensive 1D and 2D NMR spectroscopic interpretation. All five compounds inhibited DNA polymerase β lyase activity.",

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AU - Gao, Zhijie

AU - Hecht, Sidney M.

AU - Jones, Shannon H.

AU - Kingston, David G.I.

PY - 2003/11

Y1 - 2003/11

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AB - Bioassay-directed fractionation of a n-hexane extract of Couepia polyandra using an assay to detect inhibitors of the lyase activity of DNA polymerase β resulted in the isolation of the new triterpene 3β,16β ,23-triacetoxyolean-12-en-28-oic acid (1) and four known compounds, oleanolic acid, betulinic acid, stigmasterol, and β-sitosterol. The structure of the new compound was established on the basis of extensive 1D and 2D NMR spectroscopic interpretation. All five compounds inhibited DNA polymerase β lyase activity.

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A New Acylated Oleanane Triterpenoid from Couepia polyandra that Inhibits the Lyase Activity of DNA Polymerase β

Abstract

ASJC Scopus subject areas

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