A New Acylated Oleanane Triterpenoid from Couepia polyandra that Inhibits the Lyase Activity of DNA Polymerase β

V. S. Prakash Chaturvedula, Zhijie Gao, Sidney M. Hecht, Shannon H. Jones, David G.I. Kingston

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Bioassay-directed fractionation of a n-hexane extract of Couepia polyandra using an assay to detect inhibitors of the lyase activity of DNA polymerase β resulted in the isolation of the new triterpene 3β,16β ,23-triacetoxyolean-12-en-28-oic acid (1) and four known compounds, oleanolic acid, betulinic acid, stigmasterol, and β-sitosterol. The structure of the new compound was established on the basis of extensive 1D and 2D NMR spectroscopic interpretation. All five compounds inhibited DNA polymerase β lyase activity.

Original languageEnglish (US)
Pages (from-to)1463-1465
Number of pages3
JournalJournal of Natural Products
Volume66
Issue number11
DOIs
StatePublished - Nov 2003

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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