A multiparametric biosensor array for on-chip cell culture with feedback controlled microfluidics

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We present work towards expanding the capabilities of microfluidic cell culture devices through the incorporation of microelectronic sensing systems. A system has been fabricated that includes four sensing regions each consisting of a pH sensor, capacitance sensor, and photodiode. We have demonstrated the incorporation of feedback control systems using computer controlled microfluidics for a pH sensor. Preliminary data for photodiode characterization, pH detection using ISFETs, and capacitance sensing of cell density is presented. Results from this work will be used towards creating a single system that can function as a cell culture platform with programmable control over all of these variables.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE International Symposium on Circuits and Systems
Pages809-812
Number of pages4
DOIs
StatePublished - 2011
Event2011 IEEE International Symposium of Circuits and Systems, ISCAS 2011 - Rio de Janeiro, Brazil
Duration: May 15 2011May 18 2011

Other

Other2011 IEEE International Symposium of Circuits and Systems, ISCAS 2011
CountryBrazil
CityRio de Janeiro
Period5/15/115/18/11

Fingerprint

pH sensors
Photodiodes
Cell culture
Microfluidics
Biosensors
Capacitance
Ion sensitive field effect transistors
Feedback
Microelectronics
Feedback control
Control systems
Sensors

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Welch, D., & Blain Christen, J. (2011). A multiparametric biosensor array for on-chip cell culture with feedback controlled microfluidics. In Proceedings - IEEE International Symposium on Circuits and Systems (pp. 809-812). [5937689] https://doi.org/10.1109/ISCAS.2011.5937689

A multiparametric biosensor array for on-chip cell culture with feedback controlled microfluidics. / Welch, David; Blain Christen, Jennifer.

Proceedings - IEEE International Symposium on Circuits and Systems. 2011. p. 809-812 5937689.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Welch, D & Blain Christen, J 2011, A multiparametric biosensor array for on-chip cell culture with feedback controlled microfluidics. in Proceedings - IEEE International Symposium on Circuits and Systems., 5937689, pp. 809-812, 2011 IEEE International Symposium of Circuits and Systems, ISCAS 2011, Rio de Janeiro, Brazil, 5/15/11. https://doi.org/10.1109/ISCAS.2011.5937689
Welch D, Blain Christen J. A multiparametric biosensor array for on-chip cell culture with feedback controlled microfluidics. In Proceedings - IEEE International Symposium on Circuits and Systems. 2011. p. 809-812. 5937689 https://doi.org/10.1109/ISCAS.2011.5937689
Welch, David ; Blain Christen, Jennifer. / A multiparametric biosensor array for on-chip cell culture with feedback controlled microfluidics. Proceedings - IEEE International Symposium on Circuits and Systems. 2011. pp. 809-812
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