A multiparametric biosensor array for on-chip cell culture with feedback controlled microfluidics

David Welch; Jennifer Blain Christen

doi:10.1109/ISCAS.2011.5937689

A multiparametric biosensor array for on-chip cell culture with feedback controlled microfluidics

David Welch, Jennifer Blain Christen

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

We present work towards expanding the capabilities of microfluidic cell culture devices through the incorporation of microelectronic sensing systems. A system has been fabricated that includes four sensing regions each consisting of a pH sensor, capacitance sensor, and photodiode. We have demonstrated the incorporation of feedback control systems using computer controlled microfluidics for a pH sensor. Preliminary data for photodiode characterization, pH detection using ISFETs, and capacitance sensing of cell density is presented. Results from this work will be used towards creating a single system that can function as a cell culture platform with programmable control over all of these variables.

Original language	English (US)
Title of host publication	2011 IEEE International Symposium of Circuits and Systems, ISCAS 2011
Pages	809-812
Number of pages	4
DOIs	https://doi.org/10.1109/ISCAS.2011.5937689
State	Published - 2011
Event	2011 IEEE International Symposium of Circuits and Systems, ISCAS 2011 - Rio de Janeiro, Brazil Duration: May 15 2011 → May 18 2011

Publication series

Name	Proceedings - IEEE International Symposium on Circuits and Systems
ISSN (Print)	0271-4310

Other

Other	2011 IEEE International Symposium of Circuits and Systems, ISCAS 2011
Country/Territory	Brazil
City	Rio de Janeiro
Period	5/15/11 → 5/18/11

ASJC Scopus subject areas

Electrical and Electronic Engineering

Access to Document

10.1109/ISCAS.2011.5937689

Cite this

A multiparametric biosensor array for on-chip cell culture with feedback controlled microfluidics. / Welch, David; Blain Christen, Jennifer.
2011 IEEE International Symposium of Circuits and Systems, ISCAS 2011. 2011. p. 809-812 5937689 (Proceedings - IEEE International Symposium on Circuits and Systems).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Welch, D & Blain Christen, J 2011, A multiparametric biosensor array for on-chip cell culture with feedback controlled microfluidics. in 2011 IEEE International Symposium of Circuits and Systems, ISCAS 2011., 5937689, Proceedings - IEEE International Symposium on Circuits and Systems, pp. 809-812, 2011 IEEE International Symposium of Circuits and Systems, ISCAS 2011, Rio de Janeiro, Brazil, 5/15/11. https://doi.org/10.1109/ISCAS.2011.5937689

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AB - We present work towards expanding the capabilities of microfluidic cell culture devices through the incorporation of microelectronic sensing systems. A system has been fabricated that includes four sensing regions each consisting of a pH sensor, capacitance sensor, and photodiode. We have demonstrated the incorporation of feedback control systems using computer controlled microfluidics for a pH sensor. Preliminary data for photodiode characterization, pH detection using ISFETs, and capacitance sensing of cell density is presented. Results from this work will be used towards creating a single system that can function as a cell culture platform with programmable control over all of these variables.

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A multiparametric biosensor array for on-chip cell culture with feedback controlled microfluidics

Abstract

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ASJC Scopus subject areas

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