High-speed imaging combined with the optical access provided by a single-cylinder research engine offer the ability to directly study ignition and combustion phenomena. Such data provide valuable insight into the physical and chemical mechanisms important in advanced engine combustion strategies. In this study, crank-angle resolved chemiluminescence imaging data both orthogonal to and along the piston axis were used to investigate homogeneous charge compression ignition (HCCI) operation of a single-cylinder four-valve optical engine fueled using indolene. This preliminary study focused on identifying how multi-axis imaging can contribute to understanding the effects of spark-assist on HCCI performance. Operating conditions of advanced spark ignition timing for extending the lean limits of bulk charge compression ignition were used. The experiments were performed at a fixed equivalence ratio of 0 = 0.56, with fixed intake conditions (wide open throttle with air preheat). The multi-axis imaging provides a clear indication of the propagation of a reaction front from the spark kernel. The combination of orthogonal and axial views may provide valuable information spatially resolving volumetric heat release, thereby providing an indication of the fractional energy release due to the spark assist compared to the energy released by auto-ignition.