A model for the effects of primary substrates on the kinetics of reductive dehalogenation

Brian A. Wrenn, Bruce E. Rittmann

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A kinetic model that describes substrate interactions during reductive dehalogenation reactions is developed. This model describes how the concentrations of primary electron-donor and -acceptor substrates affect the rates of reductive dehalogenation reactions. A basic model, which considers only exogenous electron-donor and -acceptor substrates, illustrates the fundamental interactions that affect reductive dehalogenation reaction kinetics. Because this basic model cannot accurately describe important phenomena, such as reductive dehalogenation that occurs in the absence of exogenous electron donors, it is expanded to include an endogenous electron donor and additional electron acceptor reactions. This general model more accurately reflects the behavior that has been observed for reductive dehalogenation reactions. Under most conditions, primary electron-donor substrates stimulate the reductive dehalogenation rate, while primary electron acceptors reduce the reaction rate. The effects of primary substrates are incorporated into the kinetic parameters for a Monod-like rate expression. The apparent maximum rate of reductive dehalogenation (qm, ap) and the apparent half-saturation concentration (Kap) increase as the electron donor concentration increases. The electron-acceptor concentration does not affect qm, ap, but Kap is directly proportional to its concentration.

Original languageEnglish (US)
Pages (from-to)295-308
Number of pages14
JournalBiodegradation
Volume6
Issue number4
DOIs
StatePublished - Dec 1 1995
Externally publishedYes

Keywords

  • cometabolism
  • kinetics
  • modeling
  • reductive dehalogenation
  • substrate interactions

ASJC Scopus subject areas

  • Environmental Engineering
  • Microbiology
  • Bioengineering
  • Environmental Chemistry
  • Pollution

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