A model-based approach to synthesizing insulin infusion pump usage parameters for diabetic patients

Sriram Sankaranarayanan, Christopher Miller, Rangarajan Raghunathan, Hadi Ravanbakhsh, Georgios Fainekos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)

Abstract

We present a model-based approach to synthesizing insulin infusion pump usage parameters against varying meal scenarios and physiological conditions. Insulin infusion pumps are commonly used by type-1 diabetic patients to control their blood glucose levels. The amounts of insulin to be infused are calculated based on parameters such as insulin-to-carbohydrate ratios and correction factors that need to be calibrated carefully for each patient. Frequent and careful calibration of these parameters is essential for avoiding complications such as hypoglycemia and hyperglycemia. In this paper, we propose to synthesize optimal parameters for meal bolus calculation starting from models of the patient's insulin-glucose regulatory system and the infusion pump. Various off-the-shelf global optimization techniques are used to search for parameter values that minimize a penalty function defined over the predicted glucose sensor readings. The penalty function 'rewards' glucose levels that lie within the prescribed ranges and 'penalizes' the occurrence of hypoglycemia and hyperglycemia. We evaluate our approach using a model of the insulin-glucose regulatory system proposed by Dalla Man et al. Using this model, we compare various strategies for optimizing pump usage parameters for a virtual population of in-silico patients.

Original languageEnglish (US)
Title of host publication2012 50th Annual Allerton Conference on Communication, Control, and Computing, Allerton 2012
Pages1610-1617
Number of pages8
DOIs
StatePublished - 2012
Event2012 50th Annual Allerton Conference on Communication, Control, and Computing, Allerton 2012 - Monticello, IL, United States
Duration: Oct 1 2012Oct 5 2012

Other

Other2012 50th Annual Allerton Conference on Communication, Control, and Computing, Allerton 2012
CountryUnited States
CityMonticello, IL
Period10/1/1210/5/12

Fingerprint

Insulin
Pumps
Glucose
Glucose sensors
Global optimization
Carbohydrates
Blood
Calibration

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Computer Science Applications

Cite this

Sankaranarayanan, S., Miller, C., Raghunathan, R., Ravanbakhsh, H., & Fainekos, G. (2012). A model-based approach to synthesizing insulin infusion pump usage parameters for diabetic patients. In 2012 50th Annual Allerton Conference on Communication, Control, and Computing, Allerton 2012 (pp. 1610-1617). [6483413] https://doi.org/10.1109/Allerton.2012.6483413

A model-based approach to synthesizing insulin infusion pump usage parameters for diabetic patients. / Sankaranarayanan, Sriram; Miller, Christopher; Raghunathan, Rangarajan; Ravanbakhsh, Hadi; Fainekos, Georgios.

2012 50th Annual Allerton Conference on Communication, Control, and Computing, Allerton 2012. 2012. p. 1610-1617 6483413.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sankaranarayanan, S, Miller, C, Raghunathan, R, Ravanbakhsh, H & Fainekos, G 2012, A model-based approach to synthesizing insulin infusion pump usage parameters for diabetic patients. in 2012 50th Annual Allerton Conference on Communication, Control, and Computing, Allerton 2012., 6483413, pp. 1610-1617, 2012 50th Annual Allerton Conference on Communication, Control, and Computing, Allerton 2012, Monticello, IL, United States, 10/1/12. https://doi.org/10.1109/Allerton.2012.6483413
Sankaranarayanan S, Miller C, Raghunathan R, Ravanbakhsh H, Fainekos G. A model-based approach to synthesizing insulin infusion pump usage parameters for diabetic patients. In 2012 50th Annual Allerton Conference on Communication, Control, and Computing, Allerton 2012. 2012. p. 1610-1617. 6483413 https://doi.org/10.1109/Allerton.2012.6483413
Sankaranarayanan, Sriram ; Miller, Christopher ; Raghunathan, Rangarajan ; Ravanbakhsh, Hadi ; Fainekos, Georgios. / A model-based approach to synthesizing insulin infusion pump usage parameters for diabetic patients. 2012 50th Annual Allerton Conference on Communication, Control, and Computing, Allerton 2012. 2012. pp. 1610-1617
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