A Microsatellite-Based Multipoint Index Map of Human Chromosome 22

Kenneth H. Buetow; David Duggan; Bosheng Yang; Susan Ludwigsen; Jennifer Puck; Joanne Porter; Marcia Budarf; Richard Spielman; Beverly S. Emanuel

doi:10.1006/geno.1993.1473

A Microsatellite-Based Multipoint Index Map of Human Chromosome 22

Kenneth H. Buetow, David Duggan, Bosheng Yang, Susan Ludwigsen, Jennifer Puck, Joanne Porter, Marcia Budarf, Richard Spielman, Beverly S. Emanuel

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Utilizing the CEPH (Centre d’Etude du Polymorphisme Humain) reference panel and genotyping data for 24 simple tandem repeat polymorphism (STRP) markers, we have constructed a 15-locus multipoint genetic framework map of human chromosome 22. The markers form a continuous linkage group of 51 cM in males and 81 cM in females. Likely genetic locations are provided for 9 additional STRP sequences. The map was constructed employing the CRIMAP computational methodology to build the multipoint map via a stepwise algorithm. The quality of the framework map was evaluated using a battery of statistical diagnostics that suggest a typing error frequency of 0.1% for markers within the map.

Original language	English (US)
Pages (from-to)	329-339
Number of pages	11
Journal	Genomics
Volume	18
Issue number	2
DOIs	https://doi.org/10.1006/geno.1993.1473
State	Published - Nov 1993
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1006/geno.1993.1473

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AU - Ludwigsen, Susan

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AU - Porter, Joanne

AU - Budarf, Marcia

AU - Spielman, Richard

AU - Emanuel, Beverly S.

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AB - Utilizing the CEPH (Centre d’Etude du Polymorphisme Humain) reference panel and genotyping data for 24 simple tandem repeat polymorphism (STRP) markers, we have constructed a 15-locus multipoint genetic framework map of human chromosome 22. The markers form a continuous linkage group of 51 cM in males and 81 cM in females. Likely genetic locations are provided for 9 additional STRP sequences. The map was constructed employing the CRIMAP computational methodology to build the multipoint map via a stepwise algorithm. The quality of the framework map was evaluated using a battery of statistical diagnostics that suggest a typing error frequency of 0.1% for markers within the map.

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A Microsatellite-Based Multipoint Index Map of Human Chromosome 22

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