A Microsatellite-Based Multipoint Index Map of Human Chromosome 22

Kenneth Buetow, David Duggan, Bosheng Yang, Susan Ludwigsen, Jennifer Puck, Joanne Porter, Marcia Budarf, Richard Spielman, Beverly S. Emanuel

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Utilizing the CEPH (Centre d'Etude du Polymorphisme Humain) reference panel and genotyping data for 24 simple tandem repeat polymorphism (STRP) markers, we have constructed a 15-locus multipoint genetic framework map of human chromosome 22. The markers form a continuous linkage group of 51 cM in males and 81 cM in females. Likely genetic locations are provided for 9 additional STRP sequences. The map was constructed employing the CRIMAP computational methodology to build the multipoint map via a stepwise algorithm. The quality of the framework map was evaluated using a battery of statistical diagnostics that suggest a typing error frequency of 0.1% for markers within the map.

Original languageEnglish (US)
Pages (from-to)329-339
Number of pages11
JournalGenomics
Volume18
Issue number2
DOIs
StatePublished - Nov 1993
Externally publishedYes

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Chromosomes, Human, Pair 22
Tandem Repeat Sequences
Human Chromosomes
Microsatellite Repeats
Genetic Loci

ASJC Scopus subject areas

  • Genetics

Cite this

Buetow, K., Duggan, D., Yang, B., Ludwigsen, S., Puck, J., Porter, J., ... Emanuel, B. S. (1993). A Microsatellite-Based Multipoint Index Map of Human Chromosome 22. Genomics, 18(2), 329-339. https://doi.org/10.1006/geno.1993.1473

A Microsatellite-Based Multipoint Index Map of Human Chromosome 22. / Buetow, Kenneth; Duggan, David; Yang, Bosheng; Ludwigsen, Susan; Puck, Jennifer; Porter, Joanne; Budarf, Marcia; Spielman, Richard; Emanuel, Beverly S.

In: Genomics, Vol. 18, No. 2, 11.1993, p. 329-339.

Research output: Contribution to journalArticle

Buetow, K, Duggan, D, Yang, B, Ludwigsen, S, Puck, J, Porter, J, Budarf, M, Spielman, R & Emanuel, BS 1993, 'A Microsatellite-Based Multipoint Index Map of Human Chromosome 22', Genomics, vol. 18, no. 2, pp. 329-339. https://doi.org/10.1006/geno.1993.1473
Buetow K, Duggan D, Yang B, Ludwigsen S, Puck J, Porter J et al. A Microsatellite-Based Multipoint Index Map of Human Chromosome 22. Genomics. 1993 Nov;18(2):329-339. https://doi.org/10.1006/geno.1993.1473
Buetow, Kenneth ; Duggan, David ; Yang, Bosheng ; Ludwigsen, Susan ; Puck, Jennifer ; Porter, Joanne ; Budarf, Marcia ; Spielman, Richard ; Emanuel, Beverly S. / A Microsatellite-Based Multipoint Index Map of Human Chromosome 22. In: Genomics. 1993 ; Vol. 18, No. 2. pp. 329-339.
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