A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis

Yu Mi, Chaofeng Mu, Joy Wolfram, Zaian Deng, Tony Ye Hu, Xuewu Liu, Elvin Blanco, Haifa Shen, Mauro Ferrari

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

The successful treatment of malignant disease generally requires the use of multiple therapeutic agents that are coordinated in a spatiotemporal manner to enable synergy. Here, a porous silicon-based micro/nano composite (MNC) that is capable of simultaneously delivering chemotherapeutic agents and small interfering RNA (siRNA) to the lungs following intravenous injection is designed. The pores of the silicon microparticles are loaded with B-Raf proto-oncogene serine/threonine kinase (BRAF) siRNA-containing liposomes, while the surface is conjugated with docetaxel-encapsulated polymeric nanoparticles. The synergistic antitumor effect of the MNC is demonstrated in vitro in melanoma cells and in vivo using a mouse model for melanoma lung metastasis. The MNC displays superior therapeutic efficacy and increased accumulation in metastatic melanoma lesions in the lungs in comparison to combination therapy with liposomes and polymers. The results indicate that the MNC can be used as an effective delivery vehicle for simultaneous enrichment of multiple therapeutic agents in the lungs.

Original languageEnglish (US)
Pages (from-to)936-946
Number of pages11
JournalAdvanced Healthcare Materials
Volume5
Issue number8
DOIs
StatePublished - Apr 20 2016

Keywords

  • Biomaterials
  • Drug delivery
  • Melanoma lung metastasis
  • Polymeric materials
  • SiRNA delivery
  • Silicon microdisks

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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