A mathematical model of the dynamics for anti-HBV infection treatment with peginterferon Alfa-2a

Lequan Min; Weidong Li; Yongmei Su; Yang Kuang

doi:10.1109/ICCCAS.2008.4658004

A mathematical model of the dynamics for anti-HBV infection treatment with peginterferon Alfa-2a

Lequan Min, Weidong Li, Yongmei Su, Yang Kuang

Mathematical and Statistical Sciences, School of (SoMSS)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Abstract

Based on the anti-HBV infection therapy clinical data of the Peginterferon Alfa-2a plus placebo for HBeAg-Positive chronic hepatitis B patients, this paper establishes a mathematical model consisting of three differential equation systems and aims to describe and understand the dynamics of host cells, viruses, the immune system, as well as predict the long term curative effects. The results of numerical simulations indicate that patients whose plasma HBV DNA levels equal the mean HBV DNA levels of all patients will need to prolong their treatment time to 19 years in order to completely eliminate the HBV virus in infected hepatocytes.

Original language	English (US)
Title of host publication	2008 International Conference on Communications, Circuits and Systems Proceedings, ICCCAS 2008
Pages	1295-1298
Number of pages	4
DOIs	https://doi.org/10.1109/ICCCAS.2008.4658004
State	Published - 2008
Event	2008 International Conference on Communications, Circuits and Systems, ICCCAS 2008 - Xiamen, Fujian Province, China Duration: May 25 2008 → May 27 2008

Publication series

Name	2008 International Conference on Communications, Circuits and Systems Proceedings, ICCCAS 2008

Other

Other	2008 International Conference on Communications, Circuits and Systems, ICCCAS 2008
Country/Territory	China
City	Xiamen, Fujian Province
Period	5/25/08 → 5/27/08

ASJC Scopus subject areas

Computer Networks and Communications
Hardware and Architecture
Control and Systems Engineering
Electrical and Electronic Engineering

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10.1109/ICCCAS.2008.4658004

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Min, L., Li, W., Su, Y., & Kuang, Y. (2008). A mathematical model of the dynamics for anti-HBV infection treatment with peginterferon Alfa-2a. In 2008 International Conference on Communications, Circuits and Systems Proceedings, ICCCAS 2008 (pp. 1295-1298). [4658004] (2008 International Conference on Communications, Circuits and Systems Proceedings, ICCCAS 2008). https://doi.org/10.1109/ICCCAS.2008.4658004

A mathematical model of the dynamics for anti-HBV infection treatment with peginterferon Alfa-2a. / Min, Lequan; Li, Weidong; Su, Yongmei et al.

2008 International Conference on Communications, Circuits and Systems Proceedings, ICCCAS 2008. 2008. p. 1295-1298 4658004 (2008 International Conference on Communications, Circuits and Systems Proceedings, ICCCAS 2008).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Min, L, Li, W, Su, Y & Kuang, Y 2008, A mathematical model of the dynamics for anti-HBV infection treatment with peginterferon Alfa-2a. in 2008 International Conference on Communications, Circuits and Systems Proceedings, ICCCAS 2008., 4658004, 2008 International Conference on Communications, Circuits and Systems Proceedings, ICCCAS 2008, pp. 1295-1298, 2008 International Conference on Communications, Circuits and Systems, ICCCAS 2008, Xiamen, Fujian Province, China, 5/25/08. https://doi.org/10.1109/ICCCAS.2008.4658004

Min L, Li W, Su Y, Kuang Y. A mathematical model of the dynamics for anti-HBV infection treatment with peginterferon Alfa-2a. In 2008 International Conference on Communications, Circuits and Systems Proceedings, ICCCAS 2008. 2008. p. 1295-1298. 4658004. (2008 International Conference on Communications, Circuits and Systems Proceedings, ICCCAS 2008). doi: 10.1109/ICCCAS.2008.4658004

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AB - Based on the anti-HBV infection therapy clinical data of the Peginterferon Alfa-2a plus placebo for HBeAg-Positive chronic hepatitis B patients, this paper establishes a mathematical model consisting of three differential equation systems and aims to describe and understand the dynamics of host cells, viruses, the immune system, as well as predict the long term curative effects. The results of numerical simulations indicate that patients whose plasma HBV DNA levels equal the mean HBV DNA levels of all patients will need to prolong their treatment time to 19 years in order to completely eliminate the HBV virus in infected hepatocytes.

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A mathematical model of the dynamics for anti-HBV infection treatment with peginterferon Alfa-2a

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