A mathematical model of the dynamics for anti-HBV infection treatment with peginterferon Alfa-2a

Lequan Min, Weidong Li, Yongmei Su, Yang Kuang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Based on the anti-HBV infection therapy clinical data of the Peginterferon Alfa-2a plus placebo for HBeAg-Positive chronic hepatitis B patients, this paper establishes a mathematical model consisting of three differential equation systems and aims to describe and understand the dynamics of host cells, viruses, the immune system, as well as predict the long term curative effects. The results of numerical simulations indicate that patients whose plasma HBV DNA levels equal the mean HBV DNA levels of all patients will need to prolong their treatment time to 19 years in order to completely eliminate the HBV virus in infected hepatocytes.

Original languageEnglish (US)
Title of host publication2008 International Conference on Communications, Circuits and Systems Proceedings, ICCCAS 2008
Pages1295-1298
Number of pages4
DOIs
StatePublished - 2008
Externally publishedYes
Event2008 International Conference on Communications, Circuits and Systems, ICCCAS 2008 - Xiamen, Fujian Province, China
Duration: May 25 2008May 27 2008

Other

Other2008 International Conference on Communications, Circuits and Systems, ICCCAS 2008
CountryChina
CityXiamen, Fujian Province
Period5/25/085/27/08

Fingerprint

Viruses
DNA
Mathematical models
Immune system
Differential equations
Plasmas
Computer simulation
Hepatocytes

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Hardware and Architecture
  • Control and Systems Engineering
  • Electrical and Electronic Engineering

Cite this

Min, L., Li, W., Su, Y., & Kuang, Y. (2008). A mathematical model of the dynamics for anti-HBV infection treatment with peginterferon Alfa-2a. In 2008 International Conference on Communications, Circuits and Systems Proceedings, ICCCAS 2008 (pp. 1295-1298). [4658004] https://doi.org/10.1109/ICCCAS.2008.4658004

A mathematical model of the dynamics for anti-HBV infection treatment with peginterferon Alfa-2a. / Min, Lequan; Li, Weidong; Su, Yongmei; Kuang, Yang.

2008 International Conference on Communications, Circuits and Systems Proceedings, ICCCAS 2008. 2008. p. 1295-1298 4658004.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Min, L, Li, W, Su, Y & Kuang, Y 2008, A mathematical model of the dynamics for anti-HBV infection treatment with peginterferon Alfa-2a. in 2008 International Conference on Communications, Circuits and Systems Proceedings, ICCCAS 2008., 4658004, pp. 1295-1298, 2008 International Conference on Communications, Circuits and Systems, ICCCAS 2008, Xiamen, Fujian Province, China, 5/25/08. https://doi.org/10.1109/ICCCAS.2008.4658004
Min L, Li W, Su Y, Kuang Y. A mathematical model of the dynamics for anti-HBV infection treatment with peginterferon Alfa-2a. In 2008 International Conference on Communications, Circuits and Systems Proceedings, ICCCAS 2008. 2008. p. 1295-1298. 4658004 https://doi.org/10.1109/ICCCAS.2008.4658004
Min, Lequan ; Li, Weidong ; Su, Yongmei ; Kuang, Yang. / A mathematical model of the dynamics for anti-HBV infection treatment with peginterferon Alfa-2a. 2008 International Conference on Communications, Circuits and Systems Proceedings, ICCCAS 2008. 2008. pp. 1295-1298
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