A longitudinal study of neuropsychological change in individuals with Parkinson's disease

Tamiko Azuma, Robyn F. Cruz, Kathryn A. Bayles, Cheryl K. Tomoeda, E. B. Montgomery

    Research output: Contribution to journalArticle

    45 Citations (Scopus)

    Abstract

    Objectives: Neuropsychological changes in individuals with Parkinson's disease (PD) were studied longitudinally. Methods: Sixty-nine idiopathic PD patients, with Mini-Mental State Examination (MMSE) scores falling within normal range, and 37 elderly control participants were given neuropsychological tests twice approximately two years apart. Results: The PD group performed poorer than the control group on Semantic Fluency, Letter Fluency, Modified Wisconsin Card Sorting Task, and Block Design at test time 1. Two years later, the PD group snowed significant decline in Semantic and Letter Fluency. A subset of 12 PD patients declined in mental status by second testing (>4 MMSE points). Cox proportional-hazards models were used to see if any baseline measures were associated with relative risk of decline in mental status. In the final model, Repetition performance and Age were significantly associated with cognitive decline. Conclusions: Consistent with previous studies, executive function tasks were those most susceptible to disease progression.

    Original languageEnglish (US)
    Pages (from-to)1115-1120
    Number of pages6
    JournalInternational Journal of Geriatric Psychiatry
    Volume18
    Issue number12
    DOIs
    StatePublished - Dec 2003

    Fingerprint

    Parkinson Disease
    Longitudinal Studies
    Semantics
    Neuropsychological Tests
    Executive Function
    Proportional Hazards Models
    Disease Progression
    Reference Values
    Control Groups

    Keywords

    • Cognitive change
    • Longitudinal study
    • Parkinson's disease

    ASJC Scopus subject areas

    • Geriatrics and Gerontology
    • Psychiatry and Mental health

    Cite this

    A longitudinal study of neuropsychological change in individuals with Parkinson's disease. / Azuma, Tamiko; Cruz, Robyn F.; Bayles, Kathryn A.; Tomoeda, Cheryl K.; Montgomery, E. B.

    In: International Journal of Geriatric Psychiatry, Vol. 18, No. 12, 12.2003, p. 1115-1120.

    Research output: Contribution to journalArticle

    Azuma, Tamiko ; Cruz, Robyn F. ; Bayles, Kathryn A. ; Tomoeda, Cheryl K. ; Montgomery, E. B. / A longitudinal study of neuropsychological change in individuals with Parkinson's disease. In: International Journal of Geriatric Psychiatry. 2003 ; Vol. 18, No. 12. pp. 1115-1120.
    @article{280325eae596424789f149d3fc8ca916,
    title = "A longitudinal study of neuropsychological change in individuals with Parkinson's disease",
    abstract = "Objectives: Neuropsychological changes in individuals with Parkinson's disease (PD) were studied longitudinally. Methods: Sixty-nine idiopathic PD patients, with Mini-Mental State Examination (MMSE) scores falling within normal range, and 37 elderly control participants were given neuropsychological tests twice approximately two years apart. Results: The PD group performed poorer than the control group on Semantic Fluency, Letter Fluency, Modified Wisconsin Card Sorting Task, and Block Design at test time 1. Two years later, the PD group snowed significant decline in Semantic and Letter Fluency. A subset of 12 PD patients declined in mental status by second testing (>4 MMSE points). Cox proportional-hazards models were used to see if any baseline measures were associated with relative risk of decline in mental status. In the final model, Repetition performance and Age were significantly associated with cognitive decline. Conclusions: Consistent with previous studies, executive function tasks were those most susceptible to disease progression.",
    keywords = "Cognitive change, Longitudinal study, Parkinson's disease",
    author = "Tamiko Azuma and Cruz, {Robyn F.} and Bayles, {Kathryn A.} and Tomoeda, {Cheryl K.} and Montgomery, {E. B.}",
    year = "2003",
    month = "12",
    doi = "10.1002/gps.1022",
    language = "English (US)",
    volume = "18",
    pages = "1115--1120",
    journal = "International Journal of Geriatric Psychiatry",
    issn = "0885-6230",
    publisher = "John Wiley and Sons Ltd",
    number = "12",

    }

    TY - JOUR

    T1 - A longitudinal study of neuropsychological change in individuals with Parkinson's disease

    AU - Azuma, Tamiko

    AU - Cruz, Robyn F.

    AU - Bayles, Kathryn A.

    AU - Tomoeda, Cheryl K.

    AU - Montgomery, E. B.

    PY - 2003/12

    Y1 - 2003/12

    N2 - Objectives: Neuropsychological changes in individuals with Parkinson's disease (PD) were studied longitudinally. Methods: Sixty-nine idiopathic PD patients, with Mini-Mental State Examination (MMSE) scores falling within normal range, and 37 elderly control participants were given neuropsychological tests twice approximately two years apart. Results: The PD group performed poorer than the control group on Semantic Fluency, Letter Fluency, Modified Wisconsin Card Sorting Task, and Block Design at test time 1. Two years later, the PD group snowed significant decline in Semantic and Letter Fluency. A subset of 12 PD patients declined in mental status by second testing (>4 MMSE points). Cox proportional-hazards models were used to see if any baseline measures were associated with relative risk of decline in mental status. In the final model, Repetition performance and Age were significantly associated with cognitive decline. Conclusions: Consistent with previous studies, executive function tasks were those most susceptible to disease progression.

    AB - Objectives: Neuropsychological changes in individuals with Parkinson's disease (PD) were studied longitudinally. Methods: Sixty-nine idiopathic PD patients, with Mini-Mental State Examination (MMSE) scores falling within normal range, and 37 elderly control participants were given neuropsychological tests twice approximately two years apart. Results: The PD group performed poorer than the control group on Semantic Fluency, Letter Fluency, Modified Wisconsin Card Sorting Task, and Block Design at test time 1. Two years later, the PD group snowed significant decline in Semantic and Letter Fluency. A subset of 12 PD patients declined in mental status by second testing (>4 MMSE points). Cox proportional-hazards models were used to see if any baseline measures were associated with relative risk of decline in mental status. In the final model, Repetition performance and Age were significantly associated with cognitive decline. Conclusions: Consistent with previous studies, executive function tasks were those most susceptible to disease progression.

    KW - Cognitive change

    KW - Longitudinal study

    KW - Parkinson's disease

    UR - http://www.scopus.com/inward/record.url?scp=0346368389&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0346368389&partnerID=8YFLogxK

    U2 - 10.1002/gps.1022

    DO - 10.1002/gps.1022

    M3 - Article

    C2 - 14677144

    AN - SCOPUS:0346368389

    VL - 18

    SP - 1115

    EP - 1120

    JO - International Journal of Geriatric Psychiatry

    JF - International Journal of Geriatric Psychiatry

    SN - 0885-6230

    IS - 12

    ER -