A light-reflecting balloon catheter for atraumatic tissue defect repair

Ellen T. Roche, Assunta Fabozzo, Yuhan Lee, Panagiotis Polygerinos, Ingeborg Friehs, Lucia Schuster, William Whyte, Alejandra Maria Casar Berazaluce, Alejandra Bueno, Nora Lang, Maria J N Pereira, Eric Feins, Steven Wasserman, Eoin D. O'Cearbhaill, Nikolay V. Vasilyev, David J. Mooney, Jeffrey M. Karp, Pedro J. Del Nido, Conor J. Walsh

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A congenital or iatrogenic tissue defect often requires closure by open surgery or metallic components that can erode tissue. Biodegradable, hydrophobic light-activated adhesives represent an attractive alternative to sutures, but lack a specifically designed minimally invasive delivery tool, which limits their clinical translation. We developed a multifunctional, catheter-based technology with no implantable rigid components that functions by unfolding an adhesive-loaded elastic patch and deploying a double-balloon design to stabilize and apply pressure to the patch against the tissue defect site. The device uses a fiber-optic system and reflective metallic coating to uniformly disperse ultraviolet light for adhesive activation. Using this device, we demonstrate closure on the distal side of a defect in porcine abdominal wall, stomach, and heart tissue ex vivo. The catheter was further evaluated as a potential tool for tissue closure in vivo in rat heart and abdomen and as a perventricular tool for closure of a challenging cardiac septal defect in a large animal (porcine) model. Patches attached to the heart and abdominal wall with the device showed similar inflammatory response as sutures, with 100% small animal survival, indicating safety. In the large animal model, a ventricular septal defect in a beating heart was reduced to

Original languageEnglish (US)
JournalScience Translational Medicine
Volume7
Issue number306
DOIs
StatePublished - Sep 23 2015
Externally publishedYes

Fingerprint

Catheters
Light
Adhesives
Abdominal Wall
Equipment and Supplies
Sutures
Heart Septal Defects
Swine
Animal Models
Ventricular Heart Septal Defects
Ultraviolet Rays
Abdomen
Stomach
Technology
Safety
Pressure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Roche, E. T., Fabozzo, A., Lee, Y., Polygerinos, P., Friehs, I., Schuster, L., ... Walsh, C. J. (2015). A light-reflecting balloon catheter for atraumatic tissue defect repair. Science Translational Medicine, 7(306). https://doi.org/10.1126/scitranslmed.aaa2406

A light-reflecting balloon catheter for atraumatic tissue defect repair. / Roche, Ellen T.; Fabozzo, Assunta; Lee, Yuhan; Polygerinos, Panagiotis; Friehs, Ingeborg; Schuster, Lucia; Whyte, William; Berazaluce, Alejandra Maria Casar; Bueno, Alejandra; Lang, Nora; Pereira, Maria J N; Feins, Eric; Wasserman, Steven; O'Cearbhaill, Eoin D.; Vasilyev, Nikolay V.; Mooney, David J.; Karp, Jeffrey M.; Del Nido, Pedro J.; Walsh, Conor J.

In: Science Translational Medicine, Vol. 7, No. 306, 23.09.2015.

Research output: Contribution to journalArticle

Roche, ET, Fabozzo, A, Lee, Y, Polygerinos, P, Friehs, I, Schuster, L, Whyte, W, Berazaluce, AMC, Bueno, A, Lang, N, Pereira, MJN, Feins, E, Wasserman, S, O'Cearbhaill, ED, Vasilyev, NV, Mooney, DJ, Karp, JM, Del Nido, PJ & Walsh, CJ 2015, 'A light-reflecting balloon catheter for atraumatic tissue defect repair', Science Translational Medicine, vol. 7, no. 306. https://doi.org/10.1126/scitranslmed.aaa2406
Roche, Ellen T. ; Fabozzo, Assunta ; Lee, Yuhan ; Polygerinos, Panagiotis ; Friehs, Ingeborg ; Schuster, Lucia ; Whyte, William ; Berazaluce, Alejandra Maria Casar ; Bueno, Alejandra ; Lang, Nora ; Pereira, Maria J N ; Feins, Eric ; Wasserman, Steven ; O'Cearbhaill, Eoin D. ; Vasilyev, Nikolay V. ; Mooney, David J. ; Karp, Jeffrey M. ; Del Nido, Pedro J. ; Walsh, Conor J. / A light-reflecting balloon catheter for atraumatic tissue defect repair. In: Science Translational Medicine. 2015 ; Vol. 7, No. 306.
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