A large-scale view of the evolution of amniote development: Insights from somitogenesis in reptiles

Kenro Kusumi, Catherine M. May, Walter L. Eckalbar

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Uncovering the genetic and developmental changes that generate morphological diversity is one of the longstanding challenges in biology. The developmental process generating the spine, one of the defining features of vertebrates, constitutes one of these core questions. The vertebral column is patterned in early development through the formation of segments, called somites, regulated by gene networks collectively called the segmentation clock. While previous studies of somite development in amniotes have focused almost exclusively on the mouse and chick model systems, the growing availability of genomic sequences in other taxa has opened up the possibility of comparative developmental studies in nontraditional reptilian models, such as the anole lizard, alligator, and snake. These studies have identified conserved features of the segmentation clock, but they have also challenged previous assumptions and identified divergence in the genetic networks. Ongoing work will help to elucidate which of these morphological changes may be explained by divergences in development in amniote evolution.

Original languageEnglish (US)
Pages (from-to)491-497
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume23
Issue number4
DOIs
StatePublished - Aug 2013

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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