A high-stringency blueprint of the human proteome

Subash Adhikari; Edouard C. Nice; Eric W. Deutsch; Lydie Lane; Gilbert S. Omenn; Stephen R. Pennington; Young Ki Paik; Christopher M. Overall; Fernando J. Corrales; Ileana M. Cristea; Jennifer E. Van Eyk; Mathias Uhlén; Cecilia Lindskog; Daniel W. Chan; Amos Bairoch; James C. Waddington; Joshua L. Justice; Joshua LaBaer; Henry Rodriguez; Fuchu He; Markus Kostrzewa; Peipei Ping; Rebekah L. Gundry; Peter Stewart; Sanjeeva Srivastava; Sudhir Srivastava; Fabio C.S. Nogueira; Gilberto B. Domont; Yves Vandenbrouck; Maggie P.Y. Lam; Sara Wennersten; Juan Antonio Vizcaino; Marc Wilkins; Jochen M. Schwenk; Emma Lundberg; Nuno Bandeira; Gyorgy Marko-Varga; Susan T. Weintraub; Charles Pineau; Ulrike Kusebauch; Robert L. Moritz; Seong Beom Ahn; Magnus Palmblad; Michael P. Snyder; Ruedi Aebersold; Mark S. Baker

doi:10.1038/s41467-020-19045-9

A high-stringency blueprint of the human proteome

Subash Adhikari, Edouard C. Nice, Eric W. Deutsch, Lydie Lane, Gilbert S. Omenn, Stephen R. Pennington, Young Ki Paik, Christopher M. Overall, Fernando J. Corrales, Ileana M. Cristea, Jennifer E. Van Eyk, Mathias Uhlén, Cecilia Lindskog, Daniel W. Chan, Amos Bairoch, James C. Waddington, Joshua L. Justice, Joshua LaBaer, Henry Rodriguez, Fuchu HeMarkus Kostrzewa, Peipei Ping, Rebekah L. Gundry, Peter Stewart, Sanjeeva Srivastava, Sudhir Srivastava, Fabio C.S. Nogueira, Gilberto B. Domont, Yves Vandenbrouck, Maggie P.Y. Lam, Sara Wennersten, Juan Antonio Vizcaino, Marc Wilkins, Jochen M. Schwenk, Emma Lundberg, Nuno Bandeira, Gyorgy Marko-Varga, Susan T. Weintraub, Charles Pineau, Ulrike Kusebauch, Robert L. Moritz, Seong Beom Ahn, Magnus Palmblad, Michael P. Snyder, Ruedi Aebersold, Mark S. Baker

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Review article › peer-review

138 Scopus citations

Abstract

The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.

Original language	English (US)
Article number	5301
Journal	Nature communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-19045-9
State	Published - Dec 1 2020

ASJC Scopus subject areas

General Physics and Astronomy
General Chemistry
General Biochemistry, Genetics and Molecular Biology

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Adhikari, S., Nice, E. C., Deutsch, E. W., Lane, L., Omenn, G. S., Pennington, S. R., Paik, Y. K., Overall, C. M., Corrales, F. J., Cristea, I. M., Van Eyk, J. E., Uhlén, M., Lindskog, C., Chan, D. W., Bairoch, A., Waddington, J. C., Justice, J. L., LaBaer, J., Rodriguez, H., ... Baker, M. S. (2020). A high-stringency blueprint of the human proteome. Nature communications, 11(1), Article 5301. https://doi.org/10.1038/s41467-020-19045-9

Adhikari, S, Nice, EC, Deutsch, EW, Lane, L, Omenn, GS, Pennington, SR, Paik, YK, Overall, CM, Corrales, FJ, Cristea, IM, Van Eyk, JE, Uhlén, M, Lindskog, C, Chan, DW, Bairoch, A, Waddington, JC, Justice, JL, LaBaer, J, Rodriguez, H, He, F, Kostrzewa, M, Ping, P, Gundry, RL, Stewart, P, Srivastava, S, Srivastava, S, Nogueira, FCS, Domont, GB, Vandenbrouck, Y, Lam, MPY, Wennersten, S, Vizcaino, JA, Wilkins, M, Schwenk, JM, Lundberg, E, Bandeira, N, Marko-Varga, G, Weintraub, ST, Pineau, C, Kusebauch, U, Moritz, RL, Ahn, SB, Palmblad, M, Snyder, MP, Aebersold, R & Baker, MS 2020, 'A high-stringency blueprint of the human proteome', Nature communications, vol. 11, no. 1, 5301. https://doi.org/10.1038/s41467-020-19045-9

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abstract = "The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP{\textquoteright}s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.",

author = "Subash Adhikari and Nice, {Edouard C.} and Deutsch, {Eric W.} and Lydie Lane and Omenn, {Gilbert S.} and Pennington, {Stephen R.} and Paik, {Young Ki} and Overall, {Christopher M.} and Corrales, {Fernando J.} and Cristea, {Ileana M.} and {Van Eyk}, {Jennifer E.} and Mathias Uhl{\'e}n and Cecilia Lindskog and Chan, {Daniel W.} and Amos Bairoch and Waddington, {James C.} and Justice, {Joshua L.} and Joshua LaBaer and Henry Rodriguez and Fuchu He and Markus Kostrzewa and Peipei Ping and Gundry, {Rebekah L.} and Peter Stewart and Sanjeeva Srivastava and Sudhir Srivastava and Nogueira, {Fabio C.S.} and Domont, {Gilberto B.} and Yves Vandenbrouck and Lam, {Maggie P.Y.} and Sara Wennersten and Vizcaino, {Juan Antonio} and Marc Wilkins and Schwenk, {Jochen M.} and Emma Lundberg and Nuno Bandeira and Gyorgy Marko-Varga and Weintraub, {Susan T.} and Charles Pineau and Ulrike Kusebauch and Moritz, {Robert L.} and Ahn, {Seong Beom} and Magnus Palmblad and Snyder, {Michael P.} and Ruedi Aebersold and Baker, {Mark S.}",

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AU - Omenn, Gilbert S.

AU - Pennington, Stephen R.

AU - Paik, Young Ki

AU - Overall, Christopher M.

AU - Corrales, Fernando J.

AU - Cristea, Ileana M.

AU - Van Eyk, Jennifer E.

AU - Uhlén, Mathias

AU - Lindskog, Cecilia

AU - Chan, Daniel W.

AU - Bairoch, Amos

AU - Waddington, James C.

AU - Justice, Joshua L.

AU - LaBaer, Joshua

AU - Rodriguez, Henry

AU - He, Fuchu

AU - Kostrzewa, Markus

AU - Ping, Peipei

AU - Gundry, Rebekah L.

AU - Stewart, Peter

AU - Srivastava, Sanjeeva

AU - Srivastava, Sudhir

AU - Nogueira, Fabio C.S.

AU - Domont, Gilberto B.

AU - Vandenbrouck, Yves

AU - Lam, Maggie P.Y.

AU - Wennersten, Sara

AU - Vizcaino, Juan Antonio

AU - Wilkins, Marc

AU - Schwenk, Jochen M.

AU - Lundberg, Emma

AU - Bandeira, Nuno

AU - Marko-Varga, Gyorgy

AU - Weintraub, Susan T.

AU - Pineau, Charles

AU - Kusebauch, Ulrike

AU - Moritz, Robert L.

AU - Ahn, Seong Beom

AU - Palmblad, Magnus

AU - Snyder, Michael P.

AU - Aebersold, Ruedi

AU - Baker, Mark S.

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A high-stringency blueprint of the human proteome

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