A High-performance nanobio photocatalyst for targeted brain cancer therapy

Elena A. Rozhkova, Ilya Ulasov, Barry Lai, Nada M. Dimitrijevic, Maciej S. Lesniak, Tijana Rajh

Research output: Contribution to journalArticlepeer-review

224 Scopus citations

Abstract

We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO2 particles covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker application enables absorption of a visible part of the solar spectrum by the nanobio hybrid. The phototoxicity is mediated by reactive oxygen species (ROS) that initiate programmed death of the cancer cell. Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale.

Original languageEnglish (US)
Pages (from-to)3337-3342
Number of pages6
JournalNano Letters
Volume9
Issue number9
DOIs
StatePublished - Sep 9 2009
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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