A group contribution method for the estimation of equilibrium constants for biochemical reactions

Michael L. Mavrovouniotis, Patrick Bayol, Tu Kien Michael Lam, George Stephanopoulos, Gregory Stephanopoulos

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Using Gibbs Energies of compounds, as well as Gibbs Energy changes and equilibrium constants of biochemical reactions, the contributions of functional groups to the Gibbs Energy (in aqueous solution, temperature 25°C, and pH=7) have been estimated. These contributions allow the estimation of the Gibbs Free Energy and the equilibrium constant of a biochemical reaction, given the structure of the reactants and products.

Original languageEnglish (US)
Pages (from-to)23-28
Number of pages6
JournalBiotechnology Techniques
Volume2
Issue number1
DOIs
StatePublished - Mar 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Applied Microbiology and Biotechnology

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