A Golgi study of hypothalamic transplants in young and old host rats

Anne S. Kaplan, Don M. Gash, Dorothy G. Flood, Paul Coleman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The supraoptic nucleus of the F344 rat shows an age-related dendritic regression [17]. In order to determine whether this previously observed dendritic regression may have been related to extrinsic (to the cell) hormonal, neurotoxic, or other circulating factors unique to the hypothalamus of older brains, we conducted a quantitative Golgi study of F344 embryonic anterior hypothalamic transplants into the third ventricle of young adult (5 months) and older (25 months) male F344 rats. Three months following transplantation there were no qualitative effects of host age on neuronal morphology, nor were there quantitative effects on transplant size, dendritic length or branching frequency within the transplanted tissue. These results suggest that either (a) there were no age-related changes in factors in the host brain which were sufficient to significantly affect dendritic extent or, (b) intrinsic connections or other properties within the transplant may be important in moderating the effect of the milieu of the aged brain on the transplanted tissue.

Original languageEnglish (US)
Pages (from-to)205-211
Number of pages7
JournalNeurobiology of Aging
Volume6
Issue number3
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Inbred F344 Rats
Transplants
Brain
Supraoptic Nucleus
Third Ventricle
Hypothalamus
Young Adult
Transplantation

Keywords

  • Aging
  • Dendrites
  • Hypothalamus
  • Supraoptic nucleus
  • Transplants

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

A Golgi study of hypothalamic transplants in young and old host rats. / Kaplan, Anne S.; Gash, Don M.; Flood, Dorothy G.; Coleman, Paul.

In: Neurobiology of Aging, Vol. 6, No. 3, 01.01.1985, p. 205-211.

Research output: Contribution to journalArticle

Kaplan, Anne S. ; Gash, Don M. ; Flood, Dorothy G. ; Coleman, Paul. / A Golgi study of hypothalamic transplants in young and old host rats. In: Neurobiology of Aging. 1985 ; Vol. 6, No. 3. pp. 205-211.
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