A facile one-step in situ functionalization of quantum dots with preserved photoluminescence for bioconjugation

Qiangbin Wang, Yang Xu, Xiaohang Zhao, Yung Chang, Yan Liu, Lijing Jiang, Jaswinder Sharma, Dong Seo, Hao Yan

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Herein we report a new and simple method of in situ functionalization of CdSe QDs and surface passivation by a thin ZnS shell at the same time. This method avoids a second-step ligand exchange after the core-shell formation and preserved high quantum yield of the QDs. We demonstrated that such prepared QDs can serve as excellent nanomaterial for bioconjugation. Different antibodies were conjugated to the MPA-functionalized QDs and resulted in highly stable and highly photoluminescent nanoparticles for cell labeling purposes.

Original languageEnglish (US)
Pages (from-to)6380-6381
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number20
DOIs
StatePublished - May 23 2007

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Quantum Dots
Quantum yield
Nanostructured materials
Passivation
Antibodies
Labeling
Semiconductor quantum dots
Photoluminescence
Ligands
Nanoparticles
Nanostructures

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

A facile one-step in situ functionalization of quantum dots with preserved photoluminescence for bioconjugation. / Wang, Qiangbin; Xu, Yang; Zhao, Xiaohang; Chang, Yung; Liu, Yan; Jiang, Lijing; Sharma, Jaswinder; Seo, Dong; Yan, Hao.

In: Journal of the American Chemical Society, Vol. 129, No. 20, 23.05.2007, p. 6380-6381.

Research output: Contribution to journalArticle

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T1 - A facile one-step in situ functionalization of quantum dots with preserved photoluminescence for bioconjugation

AU - Wang, Qiangbin

AU - Xu, Yang

AU - Zhao, Xiaohang

AU - Chang, Yung

AU - Liu, Yan

AU - Jiang, Lijing

AU - Sharma, Jaswinder

AU - Seo, Dong

AU - Yan, Hao

PY - 2007/5/23

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AB - Herein we report a new and simple method of in situ functionalization of CdSe QDs and surface passivation by a thin ZnS shell at the same time. This method avoids a second-step ligand exchange after the core-shell formation and preserved high quantum yield of the QDs. We demonstrated that such prepared QDs can serve as excellent nanomaterial for bioconjugation. Different antibodies were conjugated to the MPA-functionalized QDs and resulted in highly stable and highly photoluminescent nanoparticles for cell labeling purposes.

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