A DNA nanostructure-based biomolecular probe carrier platform for electrochemical biosensing

Hao Pei; Na Lu; Yanli Wen; Shiping Song; Yan Liu; Hao Yan; Chunhai Fan

doi:10.1002/adma.201002767

A DNA nanostructure-based biomolecular probe carrier platform for electrochemical biosensing

Hao Pei, Na Lu, Yanli Wen, Shiping Song, Yan Liu, Hao Yan, Chunhai Fan

Research output: Contribution to journal › Article › peer-review

479 Scopus citations

Abstract

A 3D DNA nanostructure-based sensor platform for DNA detection has been developed. This strategy provides significantly enhanced spatial positioning range and accessibility of the probes on a surface over previously reported DNA sensing architectures. The use of this versatile DNA nanostructure-based detection platform leads to highly sensitive and selective DNA detection in biological fluids and greatly enhanced sequence specificity for SNP typing.

Original language	English (US)
Pages (from-to)	4754-4758
Number of pages	5
Journal	Advanced Materials
Volume	22
Issue number	42
DOIs	https://doi.org/10.1002/adma.201002767
State	Published - Nov 9 2010

Keywords

Aptamer
DNA hybridization
DNA nanotechnology
Electrochemical DNA sensor
Single nucleotide polymorphism

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

Access to Document

10.1002/adma.201002767

Cite this

@article{67de19a55eca4c0bb8f7a77c4bc6ac72,

title = "A DNA nanostructure-based biomolecular probe carrier platform for electrochemical biosensing",

abstract = "A 3D DNA nanostructure-based sensor platform for DNA detection has been developed. This strategy provides significantly enhanced spatial positioning range and accessibility of the probes on a surface over previously reported DNA sensing architectures. The use of this versatile DNA nanostructure-based detection platform leads to highly sensitive and selective DNA detection in biological fluids and greatly enhanced sequence specificity for SNP typing.",

keywords = "Aptamer, DNA hybridization, DNA nanotechnology, Electrochemical DNA sensor, Single nucleotide polymorphism",

author = "Hao Pei and Na Lu and Yanli Wen and Shiping Song and Yan Liu and Hao Yan and Chunhai Fan",

year = "2010",

month = nov,

day = "9",

doi = "10.1002/adma.201002767",

language = "English (US)",

volume = "22",

pages = "4754--4758",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-VCH Verlag",

number = "42",

}

TY - JOUR

T1 - A DNA nanostructure-based biomolecular probe carrier platform for electrochemical biosensing

AU - Pei, Hao

AU - Lu, Na

AU - Wen, Yanli

AU - Song, Shiping

AU - Liu, Yan

AU - Yan, Hao

AU - Fan, Chunhai

PY - 2010/11/9

Y1 - 2010/11/9

N2 - A 3D DNA nanostructure-based sensor platform for DNA detection has been developed. This strategy provides significantly enhanced spatial positioning range and accessibility of the probes on a surface over previously reported DNA sensing architectures. The use of this versatile DNA nanostructure-based detection platform leads to highly sensitive and selective DNA detection in biological fluids and greatly enhanced sequence specificity for SNP typing.

AB - A 3D DNA nanostructure-based sensor platform for DNA detection has been developed. This strategy provides significantly enhanced spatial positioning range and accessibility of the probes on a surface over previously reported DNA sensing architectures. The use of this versatile DNA nanostructure-based detection platform leads to highly sensitive and selective DNA detection in biological fluids and greatly enhanced sequence specificity for SNP typing.

KW - Aptamer

KW - DNA hybridization

KW - DNA nanotechnology

KW - Electrochemical DNA sensor

KW - Single nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=78149436155&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78149436155&partnerID=8YFLogxK

U2 - 10.1002/adma.201002767

DO - 10.1002/adma.201002767

M3 - Article

C2 - 20839255

AN - SCOPUS:78149436155

SN - 0935-9648

VL - 22

SP - 4754

EP - 4758

JO - Advanced Materials

JF - Advanced Materials

IS - 42

ER -

A DNA nanostructure-based biomolecular probe carrier platform for electrochemical biosensing

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this