A DNA-damaging oxoaporphine alkaloid from Piper caninum

Ji Ma, Shannon H. Jones, Rebekah Marshall, Randall K. Johnson, Sidney M. Hecht

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Bioassay-guided fractionation of an active organic extract of Piper caninum, using a sensitive yeast assay to monitor putative double-strand DNA-damaging activity, resulted in the isolation of the 4,5-dioxoaporphine alkaloid cepharadione A (1). Compound 1 exhibited potent inhibitory activity in a yeast cytotoxicity assay with IC50 values of 50.2 nM toward RS321NpRAD52 grown on glucose versus 293 nM toward the same yeast strain grown on galactose.

Original languageEnglish (US)
Pages (from-to)1162-1164
Number of pages3
JournalJournal of Natural Products
Volume67
Issue number7
DOIs
StatePublished - Jul 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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