A dihydroflavonol glucoside from Commiphora africana that mediates DNA strand scission

Ji Ma; Shannon H. Jones; Sidney M. Hecht

doi:10.1021/np0400510

A dihydroflavonol glucoside from Commiphora africana that mediates DNA strand scission

Ji Ma, Shannon H. Jones, Sidney M. Hecht

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A crude CH₂Cl₂-MeOH extract prepared from Commiphora africana was found to mediate Cu²⁺-dependent relaxation of supercoiled plasmid DNA. Bioassay-guided fractionation of this extract was carried out and was monitored by the use of an in vitro DNA strand scission assay. The dihydroflavonol glucoside phellamurin (1) was identified as the active principle responsible for the DNA cleavage activity of the crude extract.

Original language	English (US)
Pages (from-to)	115-117
Number of pages	3
Journal	Journal of Natural Products
Volume	68
Issue number	1
DOIs	https://doi.org/10.1021/np0400510
State	Published - Jan 2005
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np0400510

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abstract = "A crude CH2Cl2-MeOH extract prepared from Commiphora africana was found to mediate Cu2+-dependent relaxation of supercoiled plasmid DNA. Bioassay-guided fractionation of this extract was carried out and was monitored by the use of an in vitro DNA strand scission assay. The dihydroflavonol glucoside phellamurin (1) was identified as the active principle responsible for the DNA cleavage activity of the crude extract.",

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AB - A crude CH2Cl2-MeOH extract prepared from Commiphora africana was found to mediate Cu2+-dependent relaxation of supercoiled plasmid DNA. Bioassay-guided fractionation of this extract was carried out and was monitored by the use of an in vitro DNA strand scission assay. The dihydroflavonol glucoside phellamurin (1) was identified as the active principle responsible for the DNA cleavage activity of the crude extract.

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A dihydroflavonol glucoside from Commiphora africana that mediates DNA strand scission

Abstract

ASJC Scopus subject areas

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