A dihydroflavonol glucoside from Commiphora africana that mediates DNA strand scission

Ji Ma, Shannon H. Jones, Sidney M. Hecht

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

A crude CH2Cl2-MeOH extract prepared from Commiphora africana was found to mediate Cu2+-dependent relaxation of supercoiled plasmid DNA. Bioassay-guided fractionation of this extract was carried out and was monitored by the use of an in vitro DNA strand scission assay. The dihydroflavonol glucoside phellamurin (1) was identified as the active principle responsible for the DNA cleavage activity of the crude extract.

Original languageEnglish (US)
Pages (from-to)115-117
Number of pages3
JournalJournal of Natural Products
Volume68
Issue number1
DOIs
StatePublished - Jan 2005
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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