A critical analysis of the environmental dossiers from the OECD sponsorship programme for the testing of manufactured nanomaterials

Steffen Foss Hansen, Rune Hjorth, Lars Michael Skjolding, Diana Bowman, Andrew Maynard, Anders Baun

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

In 2015, the OECD finally published the findings of its seven year testing programme for manufactured nanomaterials. Here, we present the first in-depth analysis of the published OECD dossiers with regards to data on physical and chemical properties, environmental fate and ecotoxicology. Each individual study in the dossiers was reviewed with regard to, among other, which OECD Test Guidelines (TG) were used, and the reliability assigned to the study. We furthermore analyzed in detail the suspension methods used, how media quality was quantified and physical and chemical characterization performed prior, during and/or at the end of the study. We find that the information in the dossiers present an incomplete portfolio of nanomaterial ecotoxicological evaluations that are difficult to draw substantive conclusions from and that most of the studies were not designed to investigate the validity of the OECD test guidelines. We acknowledge the effort of the OECD WPMN and recommend that a follow-on program is established with well-defined goals, end-points and direct funding to qualified research laboratories to ensure valid, rigorous, reproducible and efficient research.

Original languageEnglish (US)
Pages (from-to)282-291
Number of pages10
JournalEnvironmental Science: Nano
Volume4
Issue number2
DOIs
StatePublished - 2017

ASJC Scopus subject areas

  • Materials Science (miscellaneous)
  • Environmental Science(all)

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