A critical analysis of early death after adult liver transplants

Abbas Rana, Bruce Kaplan, Tun Jie, Marian Porubsky, Shahid Habib, Horacio Rilo, Angelika C. Gruessner, Rainer W G Gruessner

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Introduction: The 15% mortality rate of liver transplant recipients at one yr may be viewed as a feat in comparison with the waiting list mortality, yet it nonetheless leaves room for much improvement. Our aim was to critically examine the mortality rates to identify high-risk periods and to incorporate cause of death into the analysis of post-transplant survival. Methods: We performed a retrospective analysis on United Network for Organ Sharing data for all adult recipients of liver transplants from January 1, 2002 to October 31, 2011. Our analysis included multivariate logistic regression where the primary outcome measure was patient death of 49 288 recipients. Results: The highest mortality rate by day post-transplant was on day 0 (0.9%). The most significant risk factors were as follows: for one-d mortality from technical failure, intensive care unit admission odds ratio (OR 3.2); for one-d mortality from graft failure, warm ischemia >75 min (OR 5.6); for one-month mortality from infection, a previous transplant (OR 3.3); and for one-month mortality from graft failure, a previous transplant (OR 3.7). Conclusion: We found that the highest mortality rate after liver transplantation is within the first day and the first month post-transplant. Those two high-risk periods have common, as well as different, risk factors for mortality.

Original languageEnglish (US)
JournalClinical Transplantation
Volume27
Issue number4
DOIs
StatePublished - Jul 2013
Externally publishedYes

Fingerprint

Transplants
Mortality
Liver
Warm Ischemia
Waiting Lists
Information Dissemination
Liver Transplantation
Intensive Care Units
Cause of Death
Multivariate Analysis
Logistic Models
Odds Ratio
Outcome Assessment (Health Care)
Infection

Keywords

  • Cause of death
  • Liver transplantation
  • Risk factors
  • Survival

ASJC Scopus subject areas

  • Transplantation

Cite this

Rana, A., Kaplan, B., Jie, T., Porubsky, M., Habib, S., Rilo, H., ... Gruessner, R. W. G. (2013). A critical analysis of early death after adult liver transplants. Clinical Transplantation, 27(4). https://doi.org/10.1111/ctr.12186

A critical analysis of early death after adult liver transplants. / Rana, Abbas; Kaplan, Bruce; Jie, Tun; Porubsky, Marian; Habib, Shahid; Rilo, Horacio; Gruessner, Angelika C.; Gruessner, Rainer W G.

In: Clinical Transplantation, Vol. 27, No. 4, 07.2013.

Research output: Contribution to journalArticle

Rana, A, Kaplan, B, Jie, T, Porubsky, M, Habib, S, Rilo, H, Gruessner, AC & Gruessner, RWG 2013, 'A critical analysis of early death after adult liver transplants', Clinical Transplantation, vol. 27, no. 4. https://doi.org/10.1111/ctr.12186
Rana, Abbas ; Kaplan, Bruce ; Jie, Tun ; Porubsky, Marian ; Habib, Shahid ; Rilo, Horacio ; Gruessner, Angelika C. ; Gruessner, Rainer W G. / A critical analysis of early death after adult liver transplants. In: Clinical Transplantation. 2013 ; Vol. 27, No. 4.
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