A coumarin from Mallotus resinosus that mediates DNA cleavage

Ji Ma, Shannon H. Jones, Sidney M. Hecht

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

A crude extract prepared from roots of Mallotus resinosus exhibited significant Cu2+-dependent DNA strand scission activity and was thus selected for bioassay-guided fractionation. Scopoletin (1), a simple cournarin, was identified as the active principle responsible for DNA cleavage activity of the crude extract. The DNA strand scission activity of 1, as well as that of three structural analogues, is reported.

Original languageEnglish (US)
Pages (from-to)1614-1616
Number of pages3
JournalJournal of Natural Products
Volume67
Issue number9
DOIs
StatePublished - Sep 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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