Abstract
A crude extract prepared from roots of Mallotus resinosus exhibited significant Cu2+-dependent DNA strand scission activity and was thus selected for bioassay-guided fractionation. Scopoletin (1), a simple cournarin, was identified as the active principle responsible for DNA cleavage activity of the crude extract. The DNA strand scission activity of 1, as well as that of three structural analogues, is reported.
Original language | English (US) |
---|---|
Pages (from-to) | 1614-1616 |
Number of pages | 3 |
Journal | Journal of Natural Products |
Volume | 67 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry