A conducting polymer nanojunction sensor for glucose detection

Erica Forzani, Haiqian Zhang, Larry A. Nagahara, Ishamshah Amlani, Raymond Tsui, Nongjian Tao

Research output: Contribution to journalArticle

205 Scopus citations

Abstract

This paper presents a glucose sensor using conducting polymer/enzyme nanojunctions and demonstrates that unique features can arise when shrinking a sensor to the nanometer scale. Each nanojunction is formed by bridging a pair of nanoelectrodes separated with a small gap (20-60 nm) with polyaniline/glucose oxidase. The signal transduction mechanism of the sensor is based on the change in the nanojunction conductance as a result of glucose oxidation induced change in the polymer redox state. Due to the small size of the nanojunction sensor, the enzyme is regenerated naturally without the need of redox mediators, which consumes minimal amount of oxygen and at the same time gives very fast response (<200 ms). These features make the nanojunction sensor potentially useful for in vivo detection of glucose.

Original languageEnglish (US)
Pages (from-to)1785-1788
Number of pages4
JournalNano Letters
Volume4
Issue number9
DOIs
StatePublished - Sep 2004

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Fingerprint Dive into the research topics of 'A conducting polymer nanojunction sensor for glucose detection'. Together they form a unique fingerprint.

  • Cite this

    Forzani, E., Zhang, H., Nagahara, L. A., Amlani, I., Tsui, R., & Tao, N. (2004). A conducting polymer nanojunction sensor for glucose detection. Nano Letters, 4(9), 1785-1788. https://doi.org/10.1021/nl049080l