A concise synthesis of the antifungal agent (+)-preussin

Mark Overhand, Sidney Hecht

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

The antifungal agent (+)-preussin (1) was synthesized in five efficient transformations from t-Boc-(S)-phenylalanine. The key step involved the Hg(II)-mediated ring closure of ynone 4, a 5-endo-dig process.

Original languageEnglish (US)
Pages (from-to)4721-4722
Number of pages2
JournalJournal of Organic Chemistry
Volume59
Issue number17
StatePublished - 1994
Externally publishedYes

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preussin
Antifungal Agents
Phenylalanine

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

A concise synthesis of the antifungal agent (+)-preussin. / Overhand, Mark; Hecht, Sidney.

In: Journal of Organic Chemistry, Vol. 59, No. 17, 1994, p. 4721-4722.

Research output: Contribution to journalArticle

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