A Concise Synthesis of the Antifungal Agent (+)-Preussin

Mark Overhand; Sidney M. Hecht

doi:10.1021/jo00096a007

A Concise Synthesis of the Antifungal Agent (+)-Preussin

Mark Overhand, Sidney M. Hecht

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

The antifungal agent (+)-preussin (1) was synthesized in five efficient transformations from t-Boc- (S)-phenylalanine. The key step involved the Hg(II)- mediated ring closure of ynone 4, a 5-endo-dig process.

Original language	English (US)
Pages (from-to)	4721-4722
Number of pages	2
Journal	Journal of Organic Chemistry
Volume	59
Issue number	17
DOIs	https://doi.org/10.1021/jo00096a007
State	Published - Aug 1 1994
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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title = "A Concise Synthesis of the Antifungal Agent (+)-Preussin",

abstract = "The antifungal agent (+)-preussin (1) was synthesized in five efficient transformations from t-Boc- (S)-phenylalanine. The key step involved the Hg(II)- mediated ring closure of ynone 4, a 5-endo-dig process.",

author = "Mark Overhand and Hecht, {Sidney M.}",

year = "1994",

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journal = "Journal of Organic Chemistry",

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AU - Overhand, Mark

AU - Hecht, Sidney M.

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AB - The antifungal agent (+)-preussin (1) was synthesized in five efficient transformations from t-Boc- (S)-phenylalanine. The key step involved the Hg(II)- mediated ring closure of ynone 4, a 5-endo-dig process.

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

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A Concise Synthesis of the Antifungal Agent (+)-Preussin

Abstract

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