A Concise Synthesis of the Antifungal Agent (+)-Preussin

Mark Overhand, Sidney M. Hecht

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

The antifungal agent (+)-preussin (1) was synthesized in five efficient transformations from t-Boc- (S)-phenylalanine. The key step involved the Hg(II)- mediated ring closure of ynone 4, a 5-endo-dig process.

Original languageEnglish (US)
Pages (from-to)4721-4722
Number of pages2
JournalJournal of Organic Chemistry
Volume59
Issue number17
DOIs
StatePublished - Aug 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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