A competitive numerical method for a chemotherapy model of two HIV subtypes

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A competitive Gauss-Seidel-type finite-difference method is developed for the solution of a non-linear deterministic model associated with the transmission dynamics of two HIV subtypes in the presence of antiretroviral therapy. The model suggests the optimal level of drug therapy coverage necessary to eradicate the disease in a given population. Unlike the standard fourth-order Runge-Kutta method (RK4), which fails when certain parameter values and time-steps are used in the discretization of the model, the new implicit finite-difference method to be developed gives stable convergent numerical results for any time-step.

Original languageEnglish (US)
Pages (from-to)329-337
Number of pages9
JournalApplied Mathematics and Computation
Volume131
Issue number2-3
DOIs
StatePublished - Sep 25 2002
Externally publishedYes

Fingerprint

Chemotherapy
Difference Method
Therapy
Numerical methods
Finite Difference
Numerical Methods
Finite difference method
Gauss-Seidel
Deterministic Model
Runge-Kutta Methods
Nonlinear Model
Fourth Order
Drug therapy
Drugs
Coverage
Runge Kutta methods
Discretization
Numerical Results
Necessary
Model

ASJC Scopus subject areas

  • Applied Mathematics
  • Computational Mathematics
  • Numerical Analysis

Cite this

A competitive numerical method for a chemotherapy model of two HIV subtypes. / Gumel, Abba.

In: Applied Mathematics and Computation, Vol. 131, No. 2-3, 25.09.2002, p. 329-337.

Research output: Contribution to journalArticle

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