A compendium of gene expression in normal human tissues.

L. L. Hsiao, F. Dangond, T. Yoshida, R. Hong, R. V. Jensen, J. Misra, W. Dillon, K. F. Lee, K. E. Clark, P. Haverty, Z. Weng, G. L. Mutter, M. P. Frosch, M. E. Macdonald, E. L. Milford, C. P. Crum, R. Bueno, R. E. Pratt, M. Mahadevappa, J. A. WarringtonG. Stephanopoulos, George Stephanopoulos, S. R. Gullans

Research output: Contribution to journalArticle

293 Citations (Scopus)

Abstract

This study creates a compendium of gene expression in normal human tissues suitable as a reference for defining basic organ systems biology. Using oligonucleotide microarrays, we analyze 59 samples representing 19 distinct tissue types. Of approximately 7,000 genes analyzed, 451 genes are expressed in all tissue types and designated as housekeeping genes. These genes display significant variation in expression levels among tissues and are sufficient for discerning tissue-specific expression signatures, indicative of fundamental differences in biochemical processes. In addition, subsets of tissue-selective genes are identified that define key biological processes characterizing each organ. This compendium highlights similarities and differences among organ systems and different individuals and also provides a publicly available resource (Human Gene Expression Index, the HuGE Index, http://www.hugeindex.org) for future studies of pathophysiology.

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalPhysiological Genomics
Volume7
Issue number2
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint

Gene Expression
Genes
Biochemical Phenomena
Biological Phenomena
Systems Biology
Essential Genes
Microarray Analysis
Oligonucleotide Array Sequence Analysis

ASJC Scopus subject areas

  • Physiology
  • Genetics

Cite this

Hsiao, L. L., Dangond, F., Yoshida, T., Hong, R., Jensen, R. V., Misra, J., ... Gullans, S. R. (2001). A compendium of gene expression in normal human tissues. Physiological Genomics, 7(2), 97-104. https://doi.org/10.1152/physiolgenomics.00040.2001

A compendium of gene expression in normal human tissues. / Hsiao, L. L.; Dangond, F.; Yoshida, T.; Hong, R.; Jensen, R. V.; Misra, J.; Dillon, W.; Lee, K. F.; Clark, K. E.; Haverty, P.; Weng, Z.; Mutter, G. L.; Frosch, M. P.; Macdonald, M. E.; Milford, E. L.; Crum, C. P.; Bueno, R.; Pratt, R. E.; Mahadevappa, M.; Warrington, J. A.; Stephanopoulos, G.; Stephanopoulos, George; Gullans, S. R.

In: Physiological Genomics, Vol. 7, No. 2, 01.01.2001, p. 97-104.

Research output: Contribution to journalArticle

Hsiao, LL, Dangond, F, Yoshida, T, Hong, R, Jensen, RV, Misra, J, Dillon, W, Lee, KF, Clark, KE, Haverty, P, Weng, Z, Mutter, GL, Frosch, MP, Macdonald, ME, Milford, EL, Crum, CP, Bueno, R, Pratt, RE, Mahadevappa, M, Warrington, JA, Stephanopoulos, G, Stephanopoulos, G & Gullans, SR 2001, 'A compendium of gene expression in normal human tissues.', Physiological Genomics, vol. 7, no. 2, pp. 97-104. https://doi.org/10.1152/physiolgenomics.00040.2001
Hsiao LL, Dangond F, Yoshida T, Hong R, Jensen RV, Misra J et al. A compendium of gene expression in normal human tissues. Physiological Genomics. 2001 Jan 1;7(2):97-104. https://doi.org/10.1152/physiolgenomics.00040.2001
Hsiao, L. L. ; Dangond, F. ; Yoshida, T. ; Hong, R. ; Jensen, R. V. ; Misra, J. ; Dillon, W. ; Lee, K. F. ; Clark, K. E. ; Haverty, P. ; Weng, Z. ; Mutter, G. L. ; Frosch, M. P. ; Macdonald, M. E. ; Milford, E. L. ; Crum, C. P. ; Bueno, R. ; Pratt, R. E. ; Mahadevappa, M. ; Warrington, J. A. ; Stephanopoulos, G. ; Stephanopoulos, George ; Gullans, S. R. / A compendium of gene expression in normal human tissues. In: Physiological Genomics. 2001 ; Vol. 7, No. 2. pp. 97-104.
@article{b1b23923b43244d09a9aa2aa2a1ef72b,
title = "A compendium of gene expression in normal human tissues.",
abstract = "This study creates a compendium of gene expression in normal human tissues suitable as a reference for defining basic organ systems biology. Using oligonucleotide microarrays, we analyze 59 samples representing 19 distinct tissue types. Of approximately 7,000 genes analyzed, 451 genes are expressed in all tissue types and designated as housekeeping genes. These genes display significant variation in expression levels among tissues and are sufficient for discerning tissue-specific expression signatures, indicative of fundamental differences in biochemical processes. In addition, subsets of tissue-selective genes are identified that define key biological processes characterizing each organ. This compendium highlights similarities and differences among organ systems and different individuals and also provides a publicly available resource (Human Gene Expression Index, the HuGE Index, http://www.hugeindex.org) for future studies of pathophysiology.",
author = "Hsiao, {L. L.} and F. Dangond and T. Yoshida and R. Hong and Jensen, {R. V.} and J. Misra and W. Dillon and Lee, {K. F.} and Clark, {K. E.} and P. Haverty and Z. Weng and Mutter, {G. L.} and Frosch, {M. P.} and Macdonald, {M. E.} and Milford, {E. L.} and Crum, {C. P.} and R. Bueno and Pratt, {R. E.} and M. Mahadevappa and Warrington, {J. A.} and G. Stephanopoulos and George Stephanopoulos and Gullans, {S. R.}",
year = "2001",
month = "1",
day = "1",
doi = "10.1152/physiolgenomics.00040.2001",
language = "English (US)",
volume = "7",
pages = "97--104",
journal = "Physiological Genomics",
issn = "1094-8341",
publisher = "American Physiological Society",
number = "2",

}

TY - JOUR

T1 - A compendium of gene expression in normal human tissues.

AU - Hsiao, L. L.

AU - Dangond, F.

AU - Yoshida, T.

AU - Hong, R.

AU - Jensen, R. V.

AU - Misra, J.

AU - Dillon, W.

AU - Lee, K. F.

AU - Clark, K. E.

AU - Haverty, P.

AU - Weng, Z.

AU - Mutter, G. L.

AU - Frosch, M. P.

AU - Macdonald, M. E.

AU - Milford, E. L.

AU - Crum, C. P.

AU - Bueno, R.

AU - Pratt, R. E.

AU - Mahadevappa, M.

AU - Warrington, J. A.

AU - Stephanopoulos, G.

AU - Stephanopoulos, George

AU - Gullans, S. R.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - This study creates a compendium of gene expression in normal human tissues suitable as a reference for defining basic organ systems biology. Using oligonucleotide microarrays, we analyze 59 samples representing 19 distinct tissue types. Of approximately 7,000 genes analyzed, 451 genes are expressed in all tissue types and designated as housekeeping genes. These genes display significant variation in expression levels among tissues and are sufficient for discerning tissue-specific expression signatures, indicative of fundamental differences in biochemical processes. In addition, subsets of tissue-selective genes are identified that define key biological processes characterizing each organ. This compendium highlights similarities and differences among organ systems and different individuals and also provides a publicly available resource (Human Gene Expression Index, the HuGE Index, http://www.hugeindex.org) for future studies of pathophysiology.

AB - This study creates a compendium of gene expression in normal human tissues suitable as a reference for defining basic organ systems biology. Using oligonucleotide microarrays, we analyze 59 samples representing 19 distinct tissue types. Of approximately 7,000 genes analyzed, 451 genes are expressed in all tissue types and designated as housekeeping genes. These genes display significant variation in expression levels among tissues and are sufficient for discerning tissue-specific expression signatures, indicative of fundamental differences in biochemical processes. In addition, subsets of tissue-selective genes are identified that define key biological processes characterizing each organ. This compendium highlights similarities and differences among organ systems and different individuals and also provides a publicly available resource (Human Gene Expression Index, the HuGE Index, http://www.hugeindex.org) for future studies of pathophysiology.

UR - http://www.scopus.com/inward/record.url?scp=0035931072&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035931072&partnerID=8YFLogxK

U2 - 10.1152/physiolgenomics.00040.2001

DO - 10.1152/physiolgenomics.00040.2001

M3 - Article

C2 - 11773596

AN - SCOPUS:0035931072

VL - 7

SP - 97

EP - 104

JO - Physiological Genomics

JF - Physiological Genomics

SN - 1094-8341

IS - 2

ER -