TY - GEN
T1 - A compact separation column for hazardous chemicals
AU - Yang, Yongmo
AU - Chae, Junseok
PY - 2007/12/1
Y1 - 2007/12/1
N2 - This paper reports a miniaturized Reverse-Phase High Performance Liquid Chromatography (HPLC) column for chemically hazardous molecules. The mini-column is designed to generate a phase delay for mixed sample molecules by the reverse-phase separation mechanism. The reverse-phase separation is performed by silica-based nano-pore beads (C-18) as stationary phase and a mixture of methanol and DI water as mobile phase. The C-18 beads are packed inside the compact chamber enclosed by a custom built PDMS (Polydimethylsiloxane) housing, equipped with microfluidic channels, inlet/outlet ports, and connectors. The mobile phase and target analytes are controlled by a syringe pump capable of manipulating two different flow rates using LabVIEW interface. The mini-column successfully separates two sample chemical molecules: Acetaminophen and Aspirin. The intensity ratio of two molecules decreases 35% from two different samples collecting at 3 and 8 min.
AB - This paper reports a miniaturized Reverse-Phase High Performance Liquid Chromatography (HPLC) column for chemically hazardous molecules. The mini-column is designed to generate a phase delay for mixed sample molecules by the reverse-phase separation mechanism. The reverse-phase separation is performed by silica-based nano-pore beads (C-18) as stationary phase and a mixture of methanol and DI water as mobile phase. The C-18 beads are packed inside the compact chamber enclosed by a custom built PDMS (Polydimethylsiloxane) housing, equipped with microfluidic channels, inlet/outlet ports, and connectors. The mobile phase and target analytes are controlled by a syringe pump capable of manipulating two different flow rates using LabVIEW interface. The mini-column successfully separates two sample chemical molecules: Acetaminophen and Aspirin. The intensity ratio of two molecules decreases 35% from two different samples collecting at 3 and 8 min.
UR - http://www.scopus.com/inward/record.url?scp=44449163544&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44449163544&partnerID=8YFLogxK
U2 - 10.1109/COASE.2007.4341842
DO - 10.1109/COASE.2007.4341842
M3 - Conference contribution
AN - SCOPUS:44449163544
SN - 1424411548
SN - 9781424411542
T3 - Proceedings of the 3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007
SP - 853
EP - 856
BT - Proceedings of the 3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007
T2 - 3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007
Y2 - 22 September 2007 through 25 September 2007
ER -