A compact separation column for hazardous chemicals

Yongmo Yang, Junseok Chae

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

This paper reports a miniaturized Reverse-Phase High Performance Liquid Chromatography (HPLC) column for chemically hazardous molecules. The mini-column is designed to generate a phase delay for mixed sample molecules by the reverse-phase separation mechanism. The reverse-phase separation is performed by silica-based nano-pore beads (C-18) as stationary phase and a mixture of methanol and DI water as mobile phase. The C-18 beads are packed inside the compact chamber enclosed by a custom built PDMS (Polydimethylsiloxane) housing, equipped with microfluidic channels, inlet/outlet ports, and connectors. The mobile phase and target analytes are controlled by a syringe pump capable of manipulating two different flow rates using LabVIEW interface. The mini-column successfully separates two sample chemical molecules: Acetaminophen and Aspirin. The intensity ratio of two molecules decreases 35% from two different samples collecting at 3 and 8 min.

Original languageEnglish (US)
Title of host publicationProceedings of the 3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007
Pages853-856
Number of pages4
DOIs
StatePublished - Dec 1 2007
Event3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007 - Scottsdale, AZ, United States
Duration: Sep 22 2007Sep 25 2007

Publication series

NameProceedings of the 3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007

Other

Other3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007
CountryUnited States
CityScottsdale, AZ
Period9/22/079/25/07

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering

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  • Cite this

    Yang, Y., & Chae, J. (2007). A compact separation column for hazardous chemicals. In Proceedings of the 3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007 (pp. 853-856). [4341842] (Proceedings of the 3rd IEEE International Conference on Automation Science and Engineering, IEEE CASE 2007). https://doi.org/10.1109/COASE.2007.4341842