A combination vaccine confers full protection against co-infections with influenza, herpes simplex and respiratory syncytial viruses

Adel M. Talaat, Rick Lyons, Stephen Albert Johnston

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Combined/composite vaccines should be useful in reducing the number of vaccinations and provide more flexibility in confronting biological warfare scenarios. We tested the effectiveness of a composite genetic vaccine designed from previously known protective antigens directed against influenza A virus (INF-A), herpes simplex virus type-1 (HSV-1) and respiratory syncytial virus (RSV) in a mouse-based challenge. Immunizing mice with a pool of four plasmids; INF-A haemagglutinin (HA), INF-A nucleoprotein (NP), HSV-1 glycoprotein D (gD) and RSV glycoprotein F, against the three pathogens provided full protection when mice were challenged with each pathogen. Remarkably, mice challenged with all three pathogens at once were also fully protected, even when a bacterial pathogen, Mycoplasma pulmonis, was included in the challenge. If these results are extendable to other combinations of vaccines in other hosts, it would support the development of gene vaccines as multi-component, combination vaccines.

Original languageEnglish (US)
Pages (from-to)538-544
Number of pages7
JournalVaccine
Volume20
Issue number3-4
DOIs
StatePublished - Nov 12 2001
Externally publishedYes

Keywords

  • Combination/composite vaccine
  • HSV
  • Influenza A
  • RSV

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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