A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation

Zhijun Liu, Himani Nailwal, Jonah Rector, Masmudur M. Rahman, Richard Sam, Grant McFadden, Francis Ka Ming Chan

Research output: Contribution to journalArticlepeer-review

Abstract

The orthopoxvirus vaccinia virus sensitizes cells to TNF-induced necroptosis, but it is not known whether other orthopoxviruses also sensitize cells to necroptosis. Liu et al. demonstrate that a family of orthopoxvirus viral inhibitors target RIPK3 for proteasomal degradation. This strategy critically controls viral replication and antiviral innate immunity.

Original languageEnglish (US)
Pages (from-to)247-258.e7
JournalImmunity
Volume54
Issue number2
DOIs
StatePublished - Feb 9 2021

Keywords

  • F-box
  • RIPK3
  • TNF
  • ankyrin repeats
  • cowpox virus
  • inflammation
  • necroptosis
  • poxvirus
  • ubiquitination
  • vaccinia virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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