Abstract
The orthopoxvirus vaccinia virus sensitizes cells to TNF-induced necroptosis, but it is not known whether other orthopoxviruses also sensitize cells to necroptosis. Liu et al. demonstrate that a family of orthopoxvirus viral inhibitors target RIPK3 for proteasomal degradation. This strategy critically controls viral replication and antiviral innate immunity.
Original language | English (US) |
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Pages (from-to) | 247-258.e7 |
Journal | Immunity |
Volume | 54 |
Issue number | 2 |
DOIs | |
State | Published - Feb 9 2021 |
Keywords
- F-box
- RIPK3
- TNF
- ankyrin repeats
- cowpox virus
- inflammation
- necroptosis
- poxvirus
- ubiquitination
- vaccinia virus
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases