A chronically implantable, hybrid cannula-electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals

Bradley Greger; Babak Kateb; Peter Gruen; Paul H. Patterson

doi:10.1016/j.jneumeth.2007.03.017

A chronically implantable, hybrid cannula-electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals

Bradley Greger, Babak Kateb, Peter Gruen, Paul H. Patterson

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We describe a device for assessing the effects of diffusible molecules on electrophysiological recordings from multiple neurons. This device allows for the infusion of reagents through a cannula located among an array of micro-electrodes. The device can easily be customized to target specific neural structures. It is designed to be chronically implanted so that isolated neural units and local field potentials are recorded over the course of several weeks or months. Multivariate statistical and spectral analysis of electrophysiological signals acquired using this system could quantitatively identify electrical "signatures" of therapeutically useful drugs.

Original language	English (US)
Pages (from-to)	321-325
Number of pages	5
Journal	Journal of Neuroscience Methods
Volume	163
Issue number	2
DOIs	https://doi.org/10.1016/j.jneumeth.2007.03.017
State	Published - Jul 30 2007
Externally published	Yes

Keywords

Drug delivery
Drug screening
Local field potential recording
Neural prosthetics
Single-unit recording

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.jneumeth.2007.03.017

Cite this

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title = "A chronically implantable, hybrid cannula-electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals",

abstract = "We describe a device for assessing the effects of diffusible molecules on electrophysiological recordings from multiple neurons. This device allows for the infusion of reagents through a cannula located among an array of micro-electrodes. The device can easily be customized to target specific neural structures. It is designed to be chronically implanted so that isolated neural units and local field potentials are recorded over the course of several weeks or months. Multivariate statistical and spectral analysis of electrophysiological signals acquired using this system could quantitatively identify electrical {"}signatures{"} of therapeutically useful drugs.",

keywords = "Drug delivery, Drug screening, Local field potential recording, Neural prosthetics, Single-unit recording",

author = "Bradley Greger and Babak Kateb and Peter Gruen and Patterson, {Paul H.}",

note = "Funding Information: We thank Richard Andersen for his support of this work. This work was funded by a McGrath Foundation grant to Paul H. Patterson, NIH grants R01 EY013337 and R01 EY0155445 to Richard Andersen, and NIH training grant NS007251-18 support for Bradley Greger, and the brain injury fund of Dr. Peter Gruen, which supported Babak Kateb. This work would not have been possible without the precise work of Martin Bak (Micro Probe, Inc.), who implemented the design of the cannula–electrode-pump hybrid system.",

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doi = "10.1016/j.jneumeth.2007.03.017",

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AU - Greger, Bradley

AU - Kateb, Babak

AU - Gruen, Peter

AU - Patterson, Paul H.

N1 - Funding Information: We thank Richard Andersen for his support of this work. This work was funded by a McGrath Foundation grant to Paul H. Patterson, NIH grants R01 EY013337 and R01 EY0155445 to Richard Andersen, and NIH training grant NS007251-18 support for Bradley Greger, and the brain injury fund of Dr. Peter Gruen, which supported Babak Kateb. This work would not have been possible without the precise work of Martin Bak (Micro Probe, Inc.), who implemented the design of the cannula–electrode-pump hybrid system.

PY - 2007/7/30

Y1 - 2007/7/30

N2 - We describe a device for assessing the effects of diffusible molecules on electrophysiological recordings from multiple neurons. This device allows for the infusion of reagents through a cannula located among an array of micro-electrodes. The device can easily be customized to target specific neural structures. It is designed to be chronically implanted so that isolated neural units and local field potentials are recorded over the course of several weeks or months. Multivariate statistical and spectral analysis of electrophysiological signals acquired using this system could quantitatively identify electrical "signatures" of therapeutically useful drugs.

AB - We describe a device for assessing the effects of diffusible molecules on electrophysiological recordings from multiple neurons. This device allows for the infusion of reagents through a cannula located among an array of micro-electrodes. The device can easily be customized to target specific neural structures. It is designed to be chronically implanted so that isolated neural units and local field potentials are recorded over the course of several weeks or months. Multivariate statistical and spectral analysis of electrophysiological signals acquired using this system could quantitatively identify electrical "signatures" of therapeutically useful drugs.

KW - Drug delivery

KW - Drug screening

KW - Local field potential recording

KW - Neural prosthetics

KW - Single-unit recording

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A chronically implantable, hybrid cannula-electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals

Abstract

Keywords

ASJC Scopus subject areas

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