@article{788e4dff25844576af58c316c6ac1e38,
title = "A chromosomal inversion contributes to divergence in multiple traits between deer mouse ecotypes",
abstract = "How locally adapted ecotypes are established and maintained within a species is a long-standing question in evolutionary biology. Using forest and prairie ecotypes of deer mice (Peromyscus maniculatus), we characterized the genetic basis of variation in two defining traits—tail length and coat color—and discovered a 41-megabase chromosomal inversion linked to both. The inversion frequency is 90% in the dark, long-tailed forest ecotype; decreases across a habitat transition; and is absent from the light, short-tailed prairie ecotype. We implicate divergent selection in maintaining the inversion at frequencies observed in the wild, despite high levels of gene flow, and explore fitness benefits that arise from suppressed recombination within the inversion. We uncover a key role for a large, previously uncharacterized inversion in the evolution and maintenance of classic mammalian ecotypes.",
author = "Hager, {Emily R.} and Harringmeyer, {Olivia S.} and Wooldridge, {T. Brock} and Shunn Theingi and Gable, {Jacob T.} and Sade McFadden and Beverly Neugeboren and Turner, {Kyle M.} and Jensen, {Jeffrey D.} and Hoekstra, {Hopi E.}",
note = "Funding Information: We thank C. Lewarch for assistance in the field; S. Niemi, M. Streisfeld, S. Stankowski, G. Binford, S. Bishop, K. Saunders, S. Finch, and T. Schaller for help with field logistics; K. Pritchett-Corning and S. Griggs-Collette for help establishing breeding colonies; Harvard{\textquoteright}s Office of Animal Resources for animal care; and M. Omura, J. Chupasko, M. Mullon, and J. Mewherter for help preparing and accessioning museum specimens. G. J. Kenagy, D. S. Yang, and E. Kingsley provided advice at the start of the project; P. Audano provided advice on long-read sequencing and analysis; and N. Edelman, A. Kautt, E. Kingsley, and three anonymous reviewers provided helpful feedback on the manuscript. The University of Washington Burke Museum provided specimens used in this study. This work was partially funded by Putnam Expedition grants from the Museum of Comparative Zoology (MCZ) to E.R.H., a MCZ grant-in-aid of student research to S.T., and the MCZ Chapman Fellowship for the Study of Vertebrate Locomotion to E.R.H. and J.T.G. as well as funding from the American Society of Mammalogists grants-in-aid of research to E.R.H. and O.S.H., the Harvard College Research Program to S.T., and a Society for the Study of Evolution R. C. Lewontin Early Award to O.S.H. E.R.H. was supported by an NIH training grant to Harvard{\textquoteright}s Molecules, Cells, and Organisms graduate program (NIH NIGMS T32GM007598) and by the Theodore H. Ashford Fellowship. O.S.H. was supported by a National Science Foundation (NSF) Graduate Research Fellowship, a Harvard Quantitative Biology Student Fellowship (DMS 1764269), and the Molecular Biophysics training grant (NIH NIGMS T32GM008313). J.D.J. was funded by the National Institutes of Health (1R35GM139383-01). H.E.H. is an investigator of the Howard Hughes Medical Institute. Publisher Copyright: Copyright {\textcopyright} 2022 the authors, some rights reserved",
year = "2022",
month = jul,
day = "22",
doi = "10.1126/science.abg0718",
language = "English (US)",
volume = "377",
pages = "399--405",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6604",
}