@inproceedings{f16412f7cb9d4f24b5341b3367845c7b,
title = "A cancer-specific response to suberolyanilide hydroxamic acid (saha) distinguishes MDA-MB-231 and MCF10A human breast cells in three dimensional (3-D) silicon microstructure arrays",
abstract = "We define a cancer-specific cytoarchitectural response to SAHA in human breast cells cultured on 3-D silicon micro-structure arrays. In contrast with non-malignant MCF10A breast cells, metastatic MDA-MB-231 breast cancer cells conformed to the 3-D surfaces inside the isotropic microstructures. SAHA caused cytoskeletal reorganization only in the metastatic cells which was quantified by a significant increase in cell length and area. Metastatic cells produced suspension structures containing actin filaments that raised them above the substrate and enabled them to span the 3-D structures. This finding has application to the identification of a few invasive cells in an abnormal breast lesion.",
keywords = "Cancer, Cytoarchitecture, Microarray, SAHA",
author = "Strobl, {J. S.} and M. Nikkhah and M. Agah",
year = "2010",
language = "English (US)",
isbn = "9781618390622",
series = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",
pages = "926--928",
booktitle = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",
note = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 ; Conference date: 03-10-2010 Through 07-10-2010",
}