A cancer-specific response to suberolyanilide hydroxamic acid (saha) distinguishes MDA-MB-231 and MCF10A human breast cells in three dimensional (3-D) silicon microstructure arrays

J. S. Strobl, Mehdi Nikkhah, M. Agah

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We define a cancer-specific cytoarchitectural response to SAHA in human breast cells cultured on 3-D silicon micro-structure arrays. In contrast with non-malignant MCF10A breast cells, metastatic MDA-MB-231 breast cancer cells conformed to the 3-D surfaces inside the isotropic microstructures. SAHA caused cytoskeletal reorganization only in the metastatic cells which was quantified by a significant increase in cell length and area. Metastatic cells produced suspension structures containing actin filaments that raised them above the substrate and enabled them to span the 3-D structures. This finding has application to the identification of a few invasive cells in an abnormal breast lesion.

Original languageEnglish (US)
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages926-928
Number of pages3
Volume2
StatePublished - 2010
Externally publishedYes
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: Oct 3 2010Oct 7 2010

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/3/1010/7/10

Fingerprint

Silicon
Microstructure
Acids
Cells
Substrates

Keywords

  • Cancer
  • Cytoarchitecture
  • Microarray
  • SAHA

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Strobl, J. S., Nikkhah, M., & Agah, M. (2010). A cancer-specific response to suberolyanilide hydroxamic acid (saha) distinguishes MDA-MB-231 and MCF10A human breast cells in three dimensional (3-D) silicon microstructure arrays. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (Vol. 2, pp. 926-928)

A cancer-specific response to suberolyanilide hydroxamic acid (saha) distinguishes MDA-MB-231 and MCF10A human breast cells in three dimensional (3-D) silicon microstructure arrays. / Strobl, J. S.; Nikkhah, Mehdi; Agah, M.

14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. Vol. 2 2010. p. 926-928.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Strobl, JS, Nikkhah, M & Agah, M 2010, A cancer-specific response to suberolyanilide hydroxamic acid (saha) distinguishes MDA-MB-231 and MCF10A human breast cells in three dimensional (3-D) silicon microstructure arrays. in 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. vol. 2, pp. 926-928, 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, Groningen, Netherlands, 10/3/10.
Strobl JS, Nikkhah M, Agah M. A cancer-specific response to suberolyanilide hydroxamic acid (saha) distinguishes MDA-MB-231 and MCF10A human breast cells in three dimensional (3-D) silicon microstructure arrays. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. Vol. 2. 2010. p. 926-928
Strobl, J. S. ; Nikkhah, Mehdi ; Agah, M. / A cancer-specific response to suberolyanilide hydroxamic acid (saha) distinguishes MDA-MB-231 and MCF10A human breast cells in three dimensional (3-D) silicon microstructure arrays. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. Vol. 2 2010. pp. 926-928
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