A cancer-specific response to suberolyanilide hydroxamic acid (saha) distinguishes MDA-MB-231 and MCF10A human breast cells in three dimensional (3-D) silicon microstructure arrays

J. S. Strobl, M. Nikkhah, M. Agah

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We define a cancer-specific cytoarchitectural response to SAHA in human breast cells cultured on 3-D silicon micro-structure arrays. In contrast with non-malignant MCF10A breast cells, metastatic MDA-MB-231 breast cancer cells conformed to the 3-D surfaces inside the isotropic microstructures. SAHA caused cytoskeletal reorganization only in the metastatic cells which was quantified by a significant increase in cell length and area. Metastatic cells produced suspension structures containing actin filaments that raised them above the substrate and enabled them to span the 3-D structures. This finding has application to the identification of a few invasive cells in an abnormal breast lesion.

Original languageEnglish (US)
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages926-928
Number of pages3
StatePublished - Dec 1 2010
Externally publishedYes
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: Oct 3 2010Oct 7 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume2

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/3/1010/7/10

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Keywords

  • Cancer
  • Cytoarchitecture
  • Microarray
  • SAHA

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Strobl, J. S., Nikkhah, M., & Agah, M. (2010). A cancer-specific response to suberolyanilide hydroxamic acid (saha) distinguishes MDA-MB-231 and MCF10A human breast cells in three dimensional (3-D) silicon microstructure arrays. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 926-928). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 2).