A biomarker of mercury body-burden correlated with diagnostic domain specific clinical symptoms of autism spectrum disorder

Janet K. Kern, David A. Geier, James Adams, Mark R. Geier

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The study purpose was to compare the quantitative results from tests for urinary porphyrins, where some of these porphyrins are known biomarkers of heavy metal toxicity, to the independent assessments from a recognized quantitative measurement, the Autism Treatment Evaluation Checklist (ATEC), of specific domains of autistic disorders symptoms (Speech/Language, Sociability, Sensory/Cognitive Awareness, and Health/Physical/Behavior) in a group of children having a clinical diagnosis of autism spectrum disorder (ASD). After a Childhood Autism Rating Scale (CARS) evaluation to assess the development of each child in this study and aid in confirming their classification, and an ATEC was completed by a parent, a urinary porphyrin profile sample was collected and sent out for blinded analysis. Urinary porphyrins from twenty-four children, 2-13 years of age, diagnosed with autism or PDD-NOS were compared to their ATEC scores as well as their scores in the specific domains (Speech/Language, Sociability, Sensory/Cognitive Awareness, and Health/Physical/Behavior) assessed by ATEC. Their urinary porphyrin samples were evaluated at Laboratoire Philippe Auguste (which is an ISO-approved clinical laboratory). The results of the study indicated that the participants' overall ATEC scores and their scores on each of the ATEC subscales (Speech/Language, Sociability, Sensory/Cognitive Awareness, and Health/Physical/Behavior) were linearly related to urinary porphyrins associated with mercury toxicity. The results show an association between the apparent level of mercury toxicity as measured by recognized urinary porphyrin biomarkers of mercury toxicity and the magnitude of the specific hallmark features of autism as assessed by ATEC.

Original languageEnglish (US)
Pages (from-to)1043-1051
Number of pages9
JournalBioMetals
Volume23
Issue number6
DOIs
StatePublished - Dec 2010

Fingerprint

Body Burden
Porphyrins
Biomarkers
Autistic Disorder
Mercury
mercury
signs and symptoms (animals and humans)
biomarkers
porphyrins
Checklist
Toxicity
Health
toxicity
Language
Clinical laboratories
Therapeutics
Heavy Metals
Autism Spectrum Disorder
autism
Heavy metals

Keywords

  • ASDs
  • Asperger's
  • ATEC
  • Autism
  • Biomarkers
  • CARS
  • Mercury
  • PDD-NOS
  • Porphyrins
  • Susceptibility
  • Toxicity

ASJC Scopus subject areas

  • Biomaterials
  • Metals and Alloys
  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

A biomarker of mercury body-burden correlated with diagnostic domain specific clinical symptoms of autism spectrum disorder. / Kern, Janet K.; Geier, David A.; Adams, James; Geier, Mark R.

In: BioMetals, Vol. 23, No. 6, 12.2010, p. 1043-1051.

Research output: Contribution to journalArticle

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