A 9,000-year record of Chagas' disease

Arthur C. Aufderheide, Wilmar Salo, Michael Madden, John Streitz, Jane Buikstra, Felipe Guhl, Bernardo Arriaza, Colleen Renier, Lorentz E. Wittmers, Gino Fornaciari, Marvin Allison

Research output: Contribution to journalArticle

239 Citations (Scopus)

Abstract

Tissue specimens from 283 principally spontaneously (naturally) desiccated human mummies from coastal and low valley sites in northern Chile and southern Peru were tested with a DNA probe directed at a kinetoplast DNA segment of Trypanosoma cruzi. The time interval spanned by the eleven major cultural groups represented in the sample ranged from ≈9,000 years B.P. (7050 B.C.) to approximately the time of the Spanish conquest, ≈450 B.P. (≈1500 A.D.). Forty-one percent of the tissue extracts, amplified by the PCR reacted positively (i.e., hybridized) with the probe. Prevalence patterns demonstrated no statistically significant differences among the individual cultural groups, nor among subgroups compared on the basis of age, sex, or weight of specimen tested. These results suggest that the sylvatic (animal-infected) cycle of Chagas' disease was probably well established at the time that the earliest humans (members of the Chinchorro culture) first peopled this segment of the Andean coast and inadvertently joined the many other mammal species acting as hosts for this parasite.

Original languageEnglish (US)
Pages (from-to)2034-2039
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number7
DOIs
StatePublished - Feb 17 2004
Externally publishedYes

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Chagas Disease
Mummies
Kinetoplast DNA
Peru
Tissue Extracts
Chile
Trypanosoma cruzi
DNA Probes
Individuality
Mammals
Parasites
Weights and Measures
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

A 9,000-year record of Chagas' disease. / Aufderheide, Arthur C.; Salo, Wilmar; Madden, Michael; Streitz, John; Buikstra, Jane; Guhl, Felipe; Arriaza, Bernardo; Renier, Colleen; Wittmers, Lorentz E.; Fornaciari, Gino; Allison, Marvin.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, No. 7, 17.02.2004, p. 2034-2039.

Research output: Contribution to journalArticle

Aufderheide, AC, Salo, W, Madden, M, Streitz, J, Buikstra, J, Guhl, F, Arriaza, B, Renier, C, Wittmers, LE, Fornaciari, G & Allison, M 2004, 'A 9,000-year record of Chagas' disease', Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 7, pp. 2034-2039. https://doi.org/10.1073/pnas.0307312101
Aufderheide, Arthur C. ; Salo, Wilmar ; Madden, Michael ; Streitz, John ; Buikstra, Jane ; Guhl, Felipe ; Arriaza, Bernardo ; Renier, Colleen ; Wittmers, Lorentz E. ; Fornaciari, Gino ; Allison, Marvin. / A 9,000-year record of Chagas' disease. In: Proceedings of the National Academy of Sciences of the United States of America. 2004 ; Vol. 101, No. 7. pp. 2034-2039.
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