Find Scholarly Works

Search in all content

Filters for Scholarly Works

Search concepts
Selected Filters

Publication Year

  • 2019
  • 2018
  • 2017
  • 2015
  • 2013
  • 2012
  • 2011

Author

  • Douglas McFadden
Article

Acute myeloid leukemia targeting by myxoma virus in vivo depends on cell binding but not permissiveness to infection in vitro

Madlambayan, G. J., Bartee, E., Kim, M., Rahman, M. M., Meacham, A., Scott, E. W., McFadden, G. & Cogle, C. R., May 2012, In : Leukemia Research. 36, 5, p. 619-624 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Bugs and drugs: Oncolytic virotherapy in combination with chemotherapy

Wennier, S. T., Liu, J. & McFadden, G., Jul 2012, In : Current Pharmaceutical Biotechnology. 13, 9, p. 1817-1833 17 p.

Research output: Contribution to journalArticle

34 Scopus citations

Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function

Mahon, B. P., Ambadapadi, S., Yaron, J. R., Lomelino, C. L., Pinard, M. A., Keinan, S., Kurnikov, I., Macaulay, C., Zhang, L., Reeves, W., McFadden, D., Tibbetts, S., McKenna, R. & Lucas, A. R., Feb 20 2018, In : Biochemistry. 57, 7, p. 1096-1107 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cytokine synergy: An underappreciated contributor to innate anti-viral immunity

Bartee, E. & McFadden, G., Sep 1 2013, In : Cytokine. 63, 3, p. 237-240 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Evidence for differential viral oncolytic efficacy in an in vitro model of epithelial ovarian cancer metastasis

Tong, J. G., Valdes, Y. R., Barrett, J. W., Bell, J. C., Stojdl, D., McFadden, G., McCart, J. A., DiMattia, G. E. & Shepherd, T. G., Sep 23 2015, In : Molecular Therapy - Oncolytics. 2, p. 15013 1 p., 15013.

Research output: Contribution to journalArticle

15 Scopus citations

Evolution and divergence of the mammalian SAMD9/SAMD9L gene family

Lemos De Matos, A., Liu, J., McFadden, G. & Esteves, P. J., Jun 17 2013, In : BMC Evolutionary Biology. 13, 1, 121.

Research output: Contribution to journalArticle

23 Scopus citations

Ex Vivo Oncolytic Virotherapy with Myxoma Virus Arms Multiple Allogeneic Bone Marrow Transplant Leukocytes to Enhance Graft versus Tumor

Lilly, C. L., Villa, N. Y., Lemos de Matos, A., Ali, H. M., Dhillon, J. K. S., Hofland, T., Rahman, M. M., Chan, W., Bogen, B., Cogle, C. & McFadden, G., Mar 1 2017, In : Molecular Therapy - Oncolytics. 4, p. 31-40 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Gene delivery of a viral anti-inflammatory protein to combat ocular inflammation

Ildefonso, C. J., Jaime, H., Rahman, M. M., Li, Q., Boye, S. E., Hauswirth, W. W., Lucas, A. R., McFadden, G. & Lewin, A. S., Jan 1 2015, In : Human Gene Therapy. 26, 1, p. 59-68 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Genetic characterization of a recombinant myxoma virus in the iberian hare (Lepus granatensis)

Águeda-Pinto, A., Matos, A. L. D., Abrantes, M., Kraberger, S., Risalde, M. A., Gortázar, C., McFadden, G., Varsani, A. & Esteves, P. J., Jun 2019, In : Viruses. 11, 6, 530.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Identification of host DEAD-box RNA helicases that regulate cellular tropism of oncolytic Myxoma virus in human cancer cells

Rahman, M., Bagdassarian, E., Ali, M. A. M. & McFadden, D., Dec 1 2017, In : Scientific reports. 7, 1, 15710.

Research output: Contribution to journalArticle

8 Scopus citations

Innate immune response of human Plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain

Cao, H., Dai, P., Wang, W., Li, H., Yuan, J., Wang, F., Fang, C. M., Pitha, P. M., Liu, J., Condit, R. C., McFadden, G., Merghoub, T., Houghton, A. N., Young, J. W., Shuman, S. & Deng, L., May 14 2012, In : PloS one. 7, 5, e36823.

Research output: Contribution to journalArticle

16 Scopus citations

Intraventricular injection of myxoma virus results in transient expression of viral protein in mouse brain ependymal and subventricular cells

France, M. R., Thomas, D. L., Liu, J., McFadden, G., MacNeill, A. L. & Roy, E. J., Jan 1 2011, In : Journal of General Virology. 92, 1, p. 195-199 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

In vitro screen of a small molecule inhibitor drug library identifies multiple compounds that synergize with oncolytic myxoma virus against human brain tumor-initiating cells

McKenzie, B. A., Zemp, F. J., Pisklakova, A., Narendran, A., McFadden, D., Lun, X., Kenchappa, R. S., Kurz, E. U. & Forsyth, P. A., Jan 1 2015, In : Neuro-Oncology. 17, 8, p. 1086-1094 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

M062 is a host range factor essential for myxoma virus pathogenesis and functions as an antagonist of host SAMD9 in human cells

Liu, J., Wennier, S., Zhang, L. & McFadden, G., Apr 1 2011, In : Journal of virology. 85, 7, p. 3270-3282 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

Myxoma and vaccinia viruses bind differentially to human leukocytes

Chan, W. M., Bartee, E. C., Moreb, J. S., Dower, K., Connor, J. H. & McFadden, G., Apr 2013, In : Journal of virology. 87, 8, p. 4445-4460 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Myxomaviral anti-inflammatory serpin reduces myeloid-derived suppressor cells and human pancreatic cancer cell growth in mice

Zheng, D., Chen, H., Bartee, M. Y., Williams, J., Davids, J. A., Lomas, D. A., McFadden, G. & Lucas, A. R., 2013, In : Journal of Cancer Science and Therapy. 5, 8, p. 291-299 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Myxoma virus combined with rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors

Thomas, D. L., Doty, R., Tosic, V., Liu, J., Kranz, D. M., McFadden, G., MacNeill, A. L. & Roy, E. J., Oct 2011, In : Cancer Immunology, Immunotherapy. 60, 10, p. 1461-1472 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Myxomavirus-derived serpin prolongs survival and reduces inflammation and hemorrhage in an unrelated lethal mouse viral infection

Chen, H., Zheng, D., Abbott, J., Liu, L., Bartee, M. Y., Long, M., Davids, J., Williams, J., Feldmann, H., Strong, J., Grau, K. R., Tibbetts, S., Macaulay, C., McFadden, G., Thoburn, R., Lomas, D. A., Spinale, F. G., Virgin, H. W. & Lucas, A., Sep 2013, In : Antimicrobial Agents and Chemotherapy. 57, 9, p. 4114-4127 14 p.

Research output: Contribution to journalArticle

20 Scopus citations
4 Scopus citations

Myxoma virus induces type i interferon production in murine plasmacytoid dendritic cells via a TLR9/myd88-,IRF5/IRF7-, and IFNAR-dependent pathway

Dai, P., Cao, H., Merghoub, T., Avogadri, F., Wang, W., Parikh, T., Fang, C. M., Pitha, P. M., Fitzgerald, K. A., Rahman, M. M., McFadden, G., Hu, X., Houghton, A. N., Shuman, S. & Deng, L., Oct 2011, In : Journal of virology. 85, 20, p. 10814-10825 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Myxoma Virus Infection Promotes NK Lysis of Malignant Gliomas In Vitro and In Vivo

Ogbomo, H., Zemp, F. J., Lun, X., Zhang, J., Stack, D., Rahman, M. M., Mcfadden, G., Mody, C. H. & Forsyth, P. A., Jun 10 2013, In : PloS one. 8, 6, e66825.

Research output: Contribution to journalArticle

25 Scopus citations
35 Scopus citations

Myxoma virus M013 protein antagonizes NF-κB and inflammasome pathways via distinct structural motifs

Garg, R. R., Jackson, C. B., Rahman, M. M., Khan, A. R., Lewin, A. S. & McFadden, G., May 24 2019, In : Journal of Biological Chemistry. 294, 21, p. 8480-8489 10 p.

Research output: Contribution to journalArticle

Myxoma virus M064 Is a novel member of the poxvirus C7l superfamily of host range factors that controls the kinetics of myxomatosis in European rabbits

Liu, J., Wennier, S., Moussatche, N., Reinhard, M., Condit, R. & McFadden, G., May 2012, In : Journal of virology. 86, 9, p. 5371-5375 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Myxoma virus-mediated oncolysis of ascites-derived human ovarian cancer cells and spheroids is impacted by differential AKT activity

Correa, R. J. M., Komar, M., Tong, J. G. K., Sivapragasam, M., Rahman, M. M., McFadden, G., Dimattia, G. E. & Shepherd, T. G., May 2012, In : Gynecologic Oncology. 125, 2, p. 441-450 10 p.

Research output: Contribution to journalArticle

13 Scopus citations
31 Scopus citations

Myxoma virus sensitizes cancer cells to gemcitabine and is an effective oncolytic virotherapeutic in models of disseminated pancreatic cancer

Wennier, S. T., Liu, J., Li, S., Rahman, M. M., Mona, M. & McFadden, G., Apr 2012, In : Molecular Therapy. 20, 4, p. 759-768 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Myxoma virus suppresses proliferation of activated T lymphocytes yet permits oncolytic virus transfer to cancer cells

Villa, N. Y., Wasserfall, C. H., Meacham, A. M., Wise, E., Chan, W., Wingard, J. R., McFadden, G. & Cogle, C. R., Jun 11 2015, In : Blood. 125, 24, p. 3778-3788 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps

Jenne, C. N., Wong, C. H. Y., Zemp, F. J., McDonald, B., Rahman, M. M., Forsyth, P. A., McFadden, G. & Kubes, P., Feb 13 2013, In : Cell Host and Microbe. 13, 2, p. 169-180 12 p.

Research output: Contribution to journalArticle

190 Scopus citations

Oncolytic myxoma virus: The path to clinic

Chan, W. M., Rahman, M. M. & McFadden, G., Sep 6 2013, In : Vaccine. 31, 39, p. 4252-4258 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Oncolytic virotherapy for small-cell lung cancer induces immune infiltration and prolongs survival

Kellish, P., Shabashvili, D., Rahman, M. M., Nawab, A., Guijarro, M. V., Zhang, M., Cao, C., Moussatche, N., Boyle, T., Antonia, S., Reinhard, M., Hartzell, C., Jantz, M., Mehta, H. J., McFadden, G., Kaye, F. J. & Zajac-Kaye, M., Jun 3 2019, In : Journal of Clinical Investigation. 129, 6, p. 2279-2292 14 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Oncolytic Virus-Mediated RAS Targeting in Rhabdomyosarcoma

Phelps, M. P., Yang, H., Patel, S., Rahman, M., McFadden, D. & Chen, E., Dec 21 2018, In : Molecular Therapy - Oncolytics. 11, p. 52-61 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Parallel adaptation of rabbit populations to myxoma virus

Alves, J. M., Carneiro, M., Cheng, J. Y., de Matos, A. L., Rahman, M., Loog, L., Campos, P. F., Wales, N., Eriksson, A., Manica, A., Strive, T., Graham, S. C., Afonso, S., Bell, D. J., Belmont, L., Day, J. P., Fuller, S. J., Marchandeau, S., Palmer, W. J., Queney, G. & 9 others, Surridge, A. K., Vieira, F. G., McFadden, D., Nielsen, R., Thomas, M., Gilbert, P., Esteves, P. J., Ferrand, N. & Jiggins, F. M., Mar 22 2019, In : Science. 363, 6433, p. 1319-1326 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Positive evolutionary selection on the RIG-I-like receptor genes in mammals

Lemos De Matos, A., McFadden, G. & Esteves, P. J., Nov 27 2013, In : PloS one. 8, 11, e81864.

Research output: Contribution to journalArticle

20 Scopus citations
4 Scopus citations

Production of myxoma virus gateway entry and expression libraries and validation of viral protein expression

Smallwood, S. E., Rahman, M. M., Werden, S. J., Martino, M. F. & McFadden, G., 2011, In : Current Protocols in Microbiology. SUPPL.21

Research output: Contribution to journalArticle

2 Scopus citations

Quantifying Antibody Responses Induced by Antigen-Agnostic Immunotherapies

van Vloten, J. P., Klafuric, E. M., Karimi, K., McFadden, G., Petrik, J. J., Wootton, S. K. & Bridle, B. W., Sep 13 2019, In : Molecular Therapy - Methods and Clinical Development. 14, p. 189-196 8 p.

Research output: Contribution to journalArticle

Open Access

Quantifying Antigen-Specific T Cell Responses When Using Antigen-Agnostic Immunotherapies

van Vloten, J. P., Santry, L. A., McAusland, T. M., Karimi, K., McFadden, D., Petrik, J. J., Wootton, S. K. & Bridle, B. W., Jun 14 2019, In : Molecular Therapy - Methods and Clinical Development. 13, p. 154-166 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Resistance to Oncolytic Myxoma Virus Therapy in Nf1-/-/Trp53-/- Syngeneic Mouse Glioma Models Is Independent of Anti-Viral Type-I Interferon

Zemp, F. J., McKenzie, B. A., Lun, X., Maxwell, L., Reilly, K. M., McFadden, G., Yong, V. W. & Forsyth, P. A., Jun 6 2013, In : PloS one. 8, 6, e65801.

Research output: Contribution to journalArticle

10 Scopus citations

SAMD9 is an innate antiviral host factor with stress response properties that can be antagonized by poxviruses

Liu, J. & McFadden, G., 2015, In : Journal of virology. 89, 3, p. 1925-1931 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Selective Purging of Human Multiple Myeloma Cells from Autologous Stem Cell Transplantation Grafts using Oncolytic Myxoma Virus

Bartee, E., Chan, W. M., Moreb, J. S., Cogle, C. R. & McFadden, G., Oct 1 2012, In : Biology of Blood and Marrow Transplantation. 18, 10, p. 1540-1551 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

The Curious Road from Basic Pathogen Research to Clinical Translation

McFadden, G., Jun 1 2015, In : PLoS Pathogens. 11, 6, e1004997.

Research output: Contribution to journalArticle

1 Scopus citations

The tanapoxvirus 15L protein is a virus-encoded neuregulin that promotes viral replication in human endothelial cells

Jeng, D., Ma, Z., Barrett, J. W., McFadden, G., Loeb, J. A. & Essania, K., Mar 2013, In : Journal of virology. 87, 6, p. 3018-3026 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

The wide utility of rabbits as models of human diseases

Esteves, P. J., Abrantes, J., Baldauf, H. M., BenMohamed, L., Chen, Y., Christensen, N., González-Gallego, J., Giacani, L., Hu, J., Kaplan, G., Keppler, O. T., Knight, K. L., Kong, X. P., Lanning, D. K., Le Pendu, J., De Matos, A. L., Liu, J., Liu, S., Lopes, A. M., Lu, S. & 17 others, Lukehart, S., Manabe, Y. C., Neves, F., McFadden, D., Pan, R., Peng, X., de Sousa-Pereira, P., Pinheiro, A., Rahman, M., Ruvoën-Clouet, N., Subbian, S., Tuñón, M. J., van der Loo, W., Vaine, M., Via, L. E., Wang, S. & Mage, R., May 2018, In : Experimental and Molecular Medicine. 50, 5, 66.

Research output: Contribution to journalArticle

24 Scopus citations

The α2,3-sialyltransferase encoded by myxoma virus is a virulence factor that contributes to immunosuppression

Boutard, B., Vankerckhove, S., Markine-Goriaynoff, N., Sarlet, M., Desmecht, D., McFadden, G., Vanderplasschen, A. & Gillet, L., Feb 23 2015, In : PloS one. 10, 2, e0118806.

Research output: Contribution to journalArticle

4 Scopus citations

Treating brain tumor-initiating cells using a combination of myxoma virus and rapamycin

Zemp, F. J., Lun, X., McKenzie, B. A., Zhou, H., Maxwell, L., Sun, B., Kelly, J. J. P., Stechishin, O., Luchman, A., Weiss, S., Cairncross, J. G., Hamilton, M. G., Rabinovich, B. A., Rahman, M. M., Mohamed, M. R., Smallwood, S., Senger, D. L., Bell, J., McFadden, G. & Forsyth, P. A., Jul 2013, In : Neuro-Oncology. 15, 7, p. 904-920 17 p.

Research output: Contribution to journalArticle

24 Scopus citations

Tumor necrosis factor inhibitors from poxviruses with an emphasis on tanapoxvirus-2L protein

Jeng, D., Rahman, M. M., McFadden, G. & Essani, K., Aug 1 2011, In : Recent Patents on DNA and Gene Sequences. 5, 2, p. 97-103 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Viral serpin therapeutics: From concept to clinic

Chen, H., Zheng, D., Davids, J., Bartee, M. Y., Dai, E., Liu, L., Petrov, L., Macaulay, C., Thoburn, R., Sobel, E., Moyer, R., McFadden, D. & Lucas, A., Jun 24 2011, In : Methods in Enzymology. 499, p. 301-329 29 p.

Research output: Contribution to journalArticle

17 Scopus citations

Virotherapy using Myxoma virus prevents lethal graft-versus-host disease following xeno-transplantation with primary human hematopoietic stem cells

Bartee, E., Meacham, A., Wise, E., Cogle, C. R. & McFadden, G., Aug 14 2012, In : PloS one. 7, 8, e43298.

Research output: Contribution to journalArticle

11 Scopus citations

White paper on microbial anti-cancer therapy and prevention

Forbes, N. S., Coffin, R. S., Deng, L., Evgin, L., Fiering, S., Giacalone, M., Gravekamp, C., Gulley, J. L., Gunn, H., Hoffman, R. M., Kaur, B., Liu, K., Lyerly, H. K., Marciscano, A. E., Moradian, E., Ruppel, S., Saltzman, D. A., Tattersall, P. J., Thorne, S., Vile, R. G. & 3 others, Zhang, H. H., Zhou, S. & McFadden, D., Aug 6 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 78.

Research output: Contribution to journalArticle

18 Scopus citations