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  • Douglas McFadden

Acute myeloid leukemia targeting by myxoma virus in vivo depends on cell binding but not permissiveness to infection in vitro

Madlambayan, G. J., Bartee, E., Kim, M., Rahman, M. M., Meacham, A., Scott, E. W., McFadden, G. & Cogle, C. R., May 2012, In : Leukemia Research. 36, 5, p. 619-624 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Are We There Yet? The Smallpox Research Agenda Using Variola Virus

Damon, I. K., Damaso, C. R. & McFadden, G., May 2014, In : PLoS Pathogens. 10, 5, e1004108.

Research output: Contribution to journalArticle

14 Scopus citations

Autologous Transplantation Using Donor Leukocytes Loaded Ex Vivo with Oncolytic Myxoma Virus Can Eliminate Residual Multiple Myeloma

Villa, N. Y., Rahman, M. M., Mamola, J., D'Isabella, J., Goras, E., Kilbourne, J., Lowe, K., Daggett-Vondras, J., Torres, L., Christie, J., Appel, N., Cox, A. L., Kim, J. B. & McFadden, G., Sep 25 2020, In : Molecular Therapy - Oncolytics. 18, p. 171-188 18 p.

Research output: Contribution to journalArticle

Open Access

Bugs and drugs: Oncolytic virotherapy in combination with chemotherapy

Wennier, S. T., Liu, J. & McFadden, G., Jul 2012, In : Current Pharmaceutical Biotechnology. 13, 9, p. 1817-1833 17 p.

Research output: Contribution to journalArticle

34 Scopus citations

Building bridges between plant and animal viruses

McFadden, G. & Simon, A. E., Nov 2011, In : Current opinion in virology. 1, 5, p. 319-321 3 p.

Research output: Contribution to journalEditorial

2 Scopus citations

Cellular factors promoting resistance to effective treatment of glioma with oncolytic myxoma virus

Zemp, F. J., McKenzie, B. A., Lun, X., Reilly, K. M., McFadden, G., Yong, V. W. & Forsyth, P. A., Dec 15 2014, In : Cancer Research. 74, 24, p. 7260-7273 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Coinfections of novel polyomavirus, anelloviruses and a recombinant strain of myxoma virus-MYXV-tol identified in Iberian hares

Ägueda-Pinto, A., Kraberger, S., Lund, M. C., Gortázar, C., McFadden, G., Varsani, A. & Esteves, P. J., 2020, In : Viruses. 12, 3, 340.

Research output: Contribution to journalArticle

Open Access

Cytokine synergy: An underappreciated contributor to innate anti-viral immunity

Bartee, E. & McFadden, G., Sep 2013, In : Cytokine. 63, 3, p. 237-240 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Evolution and divergence of the mammalian SAMD9/SAMD9L gene family

Lemos De Matos, A., Liu, J., McFadden, G. & Esteves, P. J., 2013, In : BMC Evolutionary Biology. 13, 1, 121.

Research output: Contribution to journalArticle

23 Scopus citations

Evolution of viral sensing RIG-I-like receptor genes in Leporidae genera Oryctolagus, Sylvilagus, and Lepus

Lemos De Matos, A., McFadden, G. & Esteves, P. J., Jan 1 2014, In : Immunogenetics. 66, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ex vivo virotherapy with myxoma virus does not impair hematopoietic stem and progenitor cells

Villa, N. Y., Bais, S., Chan, W. M., Meacham, A. M., Wise, E., Rahman, M. M., Moreb, J. S., Rosenau, E. H., Wingard, J. R., McFadden, G. & Cogle, C. R., Mar 1 2016, In : Cytotherapy. 18, 3, p. 465-480 16 p.

Research output: Contribution to journalArticle

13 Scopus citations

Ex Vivo Virotherapy with Myxoma Virus to Treat Cancer

Villa, N. Y., Franco, L. S. & McFadden, G., Jan 1 2020, Methods in Molecular Biology. Humana Press Inc., p. 95-110 16 p. (Methods in Molecular Biology; vol. 2058).

Research output: Chapter in Book/Report/Conference proceedingChapter

Genome characterization of cetaceanpox virus from a managed Indo-Pacific bottlenose dolphin (Tursiops aduncus)

Rodrigues, T. C. S., Subramaniam, K., Varsani, A., McFadden, G., Schaefer, A. M., Bossart, G. D., Romero, C. H. & Waltzek, T. B., Mar 2020, In : Virus research. 278, 197861.

Research output: Contribution to journalArticle

Innate immune response of human Plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain

Cao, H., Dai, P., Wang, W., Li, H., Yuan, J., Wang, F., Fang, C. M., Pitha, P. M., Liu, J., Condit, R. C., McFadden, G., Merghoub, T., Houghton, A. N., Young, J. W., Shuman, S. & Deng, L., May 14 2012, In : PloS one. 7, 5, e36823.

Research output: Contribution to journalArticle

16 Scopus citations

Intraventricular injection of myxoma virus results in transient expression of viral protein in mouse brain ependymal and subventricular cells

France, M. R., Thomas, D. L., Liu, J., McFadden, G., MacNeill, A. L. & Roy, E. J., Jan 1 2011, In : Journal of General Virology. 92, 1, p. 195-199 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma

Pisklakova, A., McKenzie, B., Zemp, F., Lun, X., Kenchappa, R. S., Etame, A. B., Rahman, M. M., Reilly, K., Pilon-Thomas, S., McFadden, G., Kurz, E. & Forsyth, P. A., Aug 1 2016, In : Neuro-Oncology. 18, 8, p. 1088-1098 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

M062 is a host range factor essential for myxoma virus pathogenesis and functions as an antagonist of host SAMD9 in human cells

Liu, J., Wennier, S., Zhang, L. & McFadden, G., Apr 2011, In : Journal of virology. 85, 7, p. 3270-3282 13 p.

Research output: Contribution to journalArticle

37 Scopus citations

Mesenchymal stem cells as carriers for systemic delivery of oncolytic viruses

Hadryś, A., Sochanik, A., McFadden, G. & Jazowiecka-Rakus, J., May 5 2020, In : European Journal of Pharmacology. 874, 172991.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations

Modulation of NF-κB signalling by microbial pathogens

Rahman, M. M. & McFadden, G., Apr 2011, In : Nature Reviews Microbiology. 9, 4, p. 291-306 16 p.

Research output: Contribution to journalReview article

182 Scopus citations

Myxoma and vaccinia viruses bind differentially to human leukocytes

Chan, W. M., Bartee, E. C., Moreb, J. S., Dower, K., Connor, J. H. & McFadden, G., Apr 2013, In : Journal of virology. 87, 8, p. 4445-4460 16 p.

Research output: Contribution to journalArticle

14 Scopus citations

Myxomaviral anti-inflammatory serpin reduces myeloid-derived suppressor cells and human pancreatic cancer cell growth in mice

Zheng, D., Chen, H., Bartee, M. Y., Williams, J., Davids, J. A., Lomas, D. A., McFadden, G. & Lucas, A. R., 2013, In : Journal of Cancer Science and Therapy. 5, 8, p. 291-299 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Myxoma virus combined with rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors

Thomas, D. L., Doty, R., Tosic, V., Liu, J., Kranz, D. M., McFadden, G., MacNeill, A. L. & Roy, E. J., Oct 2011, In : Cancer Immunology, Immunotherapy. 60, 10, p. 1461-1472 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Myxomavirus-derived serpin prolongs survival and reduces inflammation and hemorrhage in an unrelated lethal mouse viral infection

Chen, H., Zheng, D., Abbott, J., Liu, L., Bartee, M. Y., Long, M., Davids, J., Williams, J., Feldmann, H., Strong, J., Grau, K. R., Tibbetts, S., Macaulay, C., McFadden, G., Thoburn, R., Lomas, D. A., Spinale, F. G., Virgin, H. W. & Lucas, A., Sep 2013, In : Antimicrobial Agents and Chemotherapy. 57, 9, p. 4114-4127 14 p.

Research output: Contribution to journalArticle

20 Scopus citations
Open Access

Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity

Tosic, V., Thomas, D. L., Kranz, D. M., Liu, J., McFadden, G., Shisler, J. L., MacNeill, A. L. & Roy, E. J., Oct 16 2014, In : PloS one. 9, 10, e109801.

Research output: Contribution to journalArticle

21 Scopus citations

Myxoma virus induces type i interferon production in murine plasmacytoid dendritic cells via a TLR9/myd88-,IRF5/IRF7-, and IFNAR-dependent pathway

Dai, P., Cao, H., Merghoub, T., Avogadri, F., Wang, W., Parikh, T., Fang, C. M., Pitha, P. M., Fitzgerald, K. A., Rahman, M. M., McFadden, G., Hu, X., Houghton, A. N., Shuman, S. & Deng, L., Oct 2011, In : Journal of virology. 85, 20, p. 10814-10825 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/Myd88-, IRF5/IRF7-, and IFNAR-dependent pathway

Dai, P., Cao, H., Merghoub, T., Avogadri, F., Wang, W., Parikh, T., Fang, C. M., Pitha, P. M., Fitzgerald, K. A., Rahman, M. M., McFadden, G., Hu, X., Houghton, A. N., Shuman, S. & Deng, L., Dec 2011, In : Journal of virology. 85, 23, p. 12835 1 p.

Research output: Contribution to journalComment/debate

3 Scopus citations

Myxoma Virus Infection Promotes NK Lysis of Malignant Gliomas In Vitro and In Vivo

Ogbomo, H., Zemp, F. J., Lun, X., Zhang, J., Stack, D., Rahman, M. M., Mcfadden, G., Mody, C. H. & Forsyth, P. A., Jun 10 2013, In : PloS one. 8, 6, e66825.

Research output: Contribution to journalArticle

25 Scopus citations
35 Scopus citations

Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma

Jazowiecka-Rakus, J., Sochanik, A., Rusin, A., Hadryś, A., Fidyk, W., Villa, N., Rahman, M. M., Chmielik, E., Franco, L. S. & McFadden, G., Sep 25 2020, In : Molecular Therapy - Oncolytics. 18, p. 335-350 16 p.

Research output: Contribution to journalArticle

Open Access

Myxoma virus M064 Is a novel member of the poxvirus C7l superfamily of host range factors that controls the kinetics of myxomatosis in European rabbits

Liu, J., Wennier, S., Moussatche, N., Reinhard, M., Condit, R. & McFadden, G., May 2012, In : Journal of virology. 86, 9, p. 5371-5375 5 p.

Research output: Contribution to journalArticle

14 Scopus citations
23 Scopus citations

Myxoma virus-mediated oncolysis of ascites-derived human ovarian cancer cells and spheroids is impacted by differential AKT activity

Correa, R. J. M., Komar, M., Tong, J. G. K., Sivapragasam, M., Rahman, M. M., McFadden, G., Dimattia, G. E. & Shepherd, T. G., May 2012, In : Gynecologic Oncology. 125, 2, p. 441-450 10 p.

Research output: Contribution to journalArticle

13 Scopus citations
31 Scopus citations

Myxoma virus sensitizes cancer cells to gemcitabine and is an effective oncolytic virotherapeutic in models of disseminated pancreatic cancer

Wennier, S. T., Liu, J., Li, S., Rahman, M. M., Mona, M. & McFadden, G., Apr 2012, In : Molecular Therapy. 20, 4, p. 759-768 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps

Jenne, C. N., Wong, C. H. Y., Zemp, F. J., McDonald, B., Rahman, M. M., Forsyth, P. A., McFadden, G. & Kubes, P., Feb 13 2013, In : Cell Host and Microbe. 13, 2, p. 169-180 12 p.

Research output: Contribution to journalArticle

195 Scopus citations

Oncolytic myxoma virus: The path to clinic

Chan, W. M., Rahman, M. M. & McFadden, G., Sep 6 2013, In : Vaccine. 31, 39, p. 4252-4258 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Oncolytic poxviruses

Chan, W. M. & McFadden, G., Sep 29 2014, In : Annual Review of Virology. 1, 1, p. 191-214 24 p.

Research output: Contribution to journalArticle

52 Scopus citations

Oncolytic virotherapy for hematological malignancies

Bais, S., Bartee, E., Rahman, M. M., McFadden, G. & Cogle, C. R., 2012, In : Advances in Virology. 2012, 186512.

Research output: Contribution to journalReview article

23 Scopus citations

Oncolytic virotherapy for pancreatic cancer.

Wennier, S., Li, S. & McFadden, G., 2011, In : Expert reviews in molecular medicine. 13, p. e18

Research output: Contribution to journalReview article

23 Scopus citations

Oncolytic Viruses and the Immune System: The Dynamic Duo

Lemos de Matos, A., Franco, L. S. & McFadden, G., Jun 12 2020, In : Molecular Therapy - Methods and Clinical Development. 17, p. 349-358 10 p.

Research output: Contribution to journalReview article

Open Access
7 Scopus citations

Positive evolutionary selection on the RIG-I-like receptor genes in mammals

Lemos De Matos, A., McFadden, G. & Esteves, P. J., Nov 27 2013, In : PloS one. 8, 11, e81864.

Research output: Contribution to journalArticle

21 Scopus citations

Poxviruses and the evolution of host range and virulence

Haller, S. L., Peng, C., McFadden, G. & Rothenburg, S., Jan 2014, In : Infection, Genetics and Evolution. 21, p. 15-40 26 p.

Research output: Contribution to journalReview article

85 Scopus citations

Production of myxoma virus gateway entry and expression libraries and validation of viral protein expression

Smallwood, S. E., Rahman, M. M., Werden, S. J., Martino, M. F. & McFadden, G., 2011, In : Current Protocols in Microbiology. SUPPL.21

Research output: Contribution to journalArticle

2 Scopus citations
7 Scopus citations

Resistance to Oncolytic Myxoma Virus Therapy in Nf1-/-/Trp53-/- Syngeneic Mouse Glioma Models Is Independent of Anti-Viral Type-I Interferon

Zemp, F. J., McKenzie, B. A., Lun, X., Maxwell, L., Reilly, K. M., McFadden, G., Yong, V. W. & Forsyth, P. A., Jun 6 2013, In : PloS one. 8, 6, e65801.

Research output: Contribution to journalArticle

10 Scopus citations

Scalable collaborative infrastructure for a learning healthcare system (SCILHS): Architecture

Mandl, K. D., Kohane, I. S., McFadden, D., Weber, G. M., Natter, M., Mandel, J., Schneeweiss, S., Weiler, S., Klann, J. G., Bickel, J., Adams, W. G., Ge, Y., Zhou, X., Perkins, J., Marsolo, K., Berns tam, E., Showalter, J., Quarshie, A., Ofili, E., Hripcsak, G. & 1 others, Murphy, S. N., 2014, In : Journal of the American Medical Informatics Association. 21, 4, p. 615-620 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Selective Purging of Human Multiple Myeloma Cells from Autologous Stem Cell Transplantation Grafts using Oncolytic Myxoma Virus

Bartee, E., Chan, W. M., Moreb, J. S., Cogle, C. R. & McFadden, G., Oct 2012, In : Biology of Blood and Marrow Transplantation. 18, 10, p. 1540-1551 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Suppression of collagen-induced arthritis with a serine proteinase inhibitor (serpin) derived from myxoma virus

Brahn, E., Lee, S., Lucas, A., McFadden, G. & MaCaulay, C., Aug 2014, In : Clinical Immunology. 153, 2, p. 254-263 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma

Tang, B., Guo, Z. S., Bartlett, D. L., Yan, D. Z., Schane, C. P., Thomas, D. L., Liu, J., McFadden, G., Shisler, J. L., Roy, E. J. & Roy, E. J., May 1 2020, In : Clinical Cancer Research. 26, 9, p. 2216-2230 15 p.

Research output: Contribution to journalArticle

2 Scopus citations